| 00:02 | So today we will continue talking about endocannabinoid system in medical cannabis and medical |
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| 00:09 | . Just the reminder that this is of the major homo static body regulatory |
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| 00:16 | but it also plays a very significant in the brain. There are certain |
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| 00:21 | of the system as you learned which the enzymes the endocannabinoid And their target |
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| 00:27 | chapter CB one and CB two You saw that these receptors in particular |
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| 00:34 | slide relates to the expression of CB receptors that is also responsible for in |
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| 00:41 | endocannabinoid system for causing a bliss happy your like effect by controlling neural transmission |
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| 00:49 | endocannabinoid but also with Fido can avenues exile exogenous cannabinoids That is also going |
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| 00:57 | be affecting different parts of the brain contains CB one and CB two |
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| 01:02 | So we talked about major parts of brain of functions here And where there |
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| 01:07 | a lot of expression of CB one . We also talked about the fact |
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| 01:11 | CB two receptors are also expressed in and glia they're more dominant and glia |
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| 01:18 | . And the other thing that we is that these CB receptors cannabinoid receptors |
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| 01:23 | the most predominantly a protein coupled receptors the brain in neurons. CB one |
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| 01:32 | through this deep polarization induced suppression of or deep polarization induced suppression of inhibition |
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| 01:39 | you have deep polarization present ethically with . You would have calcium and deep |
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| 01:44 | here production of unbroken ambulance and this feedback Retrograde fashion or travel will bind |
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| 01:51 | the CB one. This episode located synaptic terminals. They will control the |
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| 01:56 | of calcium of blocking calcium voltage gated through G protein coupled complexes and controlling |
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| 02:04 | release of glutamate. So deep polarization suppression of excitation with subsequent intimate and |
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| 02:10 | polarization induced suppression of inhibition if there too much of gathered that's being released |
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| 02:15 | there's too much austin optic stimulation. subsequently with harbor early stimulation as |
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| 02:22 | Also No CB two receptors are dominant the wheel southland particular microbial cells. |
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| 02:29 | we discussed that there instead of controlling process like neural transmission Like CB one |
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| 02:36 | CB two receptors and we are there are more concerned with the functions that |
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| 02:43 | are responsible for the microbe leah. of the functions is control of inflammatory |
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| 02:50 | and pro inflammatory side of and we the circuit behind the munchies how activation |
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| 02:59 | CB one receptor can actually enhance the of smell. So you can think |
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| 03:04 | under cannabinoids can enhance the sense of evacuating CB one receptor then exogenous spite |
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| 03:10 | phenomenons can also enhance the sense of and enhancing that sense of smell will |
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| 03:18 | appetite and will promote feeding behavior. CB 1 receptors are mostly controlling your |
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| 03:27 | CB two inflammation and we talked about few other slides in this lecture. |
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| 03:37 | what we understand about medical cannabis and society thinks about medical cannabis is created |
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| 03:48 | media and special interests and a few that ran the government And a few |
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| 03:56 | interest families that were controlling the And we're talking about 1930's immediately, |
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| 04:04 | after the end of alcohol prohibition. alcohol was illegal Until 1932. |
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| 04:14 | and then it became legal, the , this is what alcohol prohibition |
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| 04:21 | And all of a sudden there was individual in the regulatory agencies in the |
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| 04:27 | States that said that we think that and he actually said that statement on |
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| 04:33 | capitol hill in Washington D. Is the most dangerous drug and substance |
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| 04:41 | exists. And so the eradication of candidates and the long culture of using |
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| 04:50 | and candidates and medicinal preparations was deleted the time and it was of course |
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| 04:57 | by special interests by very large families were running either timber or chemical |
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| 05:05 | which is the Dupont family that had lawyers and had their process controlling the |
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| 05:14 | . The medical community never was a , cannabis, cannabis or marijuana and |
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| 05:23 | for cannabis historically used for hundreds of . And medical community even at these |
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| 05:31 | stages of cannabis prohibition at this early is the medical community was responding and |
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| 05:41 | the regulators to leave Canada's and half researched further one additional purposes, but |
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| 05:50 | was not the case. Instead. Madness has ensued. It was a |
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| 05:57 | that was created that called marijuana that cry for it and die for |
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| 06:03 | Reefer Madness. The burning section accession that makes beasts of men and women |
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| 06:13 | ng into frightful perversions, innocent youth of a new sex crazed marijuana unleashed |
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| 06:23 | . Oh my God, that sounds like the uh sex industry should have |
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| 06:28 | many different marijuana preparations by now. you know, maybe there's some truth |
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| 06:34 | stimulating some of this behavior in a sense, but not in an aggressive |
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| 06:41 | . And this hypothesis of gateway that if you basically small cannabis and |
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| 06:49 | that will lead you into harder that will lead you to this |
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| 06:54 | perverted sex behavior. And all of had very strong racial undertones. White |
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| 07:02 | , if they smoke marijuana, they go with brown men, they would |
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| 07:07 | with mexicans and they would date black . And that's just horrible. So |
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| 07:13 | was the whole thing that media was on in the public and the special |
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| 07:19 | , We're eradicating the plant to have interests from the timber or chemical factories |
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| 07:29 | by the sorts of production. The thing is that this mentality still |
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| 07:38 | If you ask some of the older and people that are not even in |
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| 07:42 | cannabis industry that are even younger people they will say, well, what |
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| 07:47 | you think? It's bad, Why it bad? Because there's a |
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| 07:54 | And if there is usually an well, it can lead to, |
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| 07:58 | a gateway drug. It's but that drug hypothesis has been disproved. Canada's |
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| 08:04 | less addictive than nicotine, that's less than Kathleen as a matter of |
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| 08:11 | Okay, so this gateway hypothesis and we know that a lot of times |
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| 08:17 | not the first thing that younger adults not Children would try in the absence |
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| 08:24 | their parents and not promoting. And think what it just happened. So |
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| 08:28 | got into my parents liquor cabinet when was six years old, that was |
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| 08:33 | first thing cigarette, you know? what is the gateway drop? But |
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| 08:40 | mentality persists and dominates the 20th century , we don't understand much about the |
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| 08:47 | until there is this to think that should understand a little bit about. |
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| 08:51 | then they have even a question for about this. It's called high performance |
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| 08:55 | chromatography and it's an analytic analytical chemistry that is used to separate identify and |
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| 09:03 | each component in the mixture. It on prompts to pass a pressurized liquid |
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| 09:09 | containing the sample mixture through a This is a column that it passes |
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| 09:15 | packing material column. Mhm filled with solid absorbent material. Each component in |
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| 09:24 | sample interacts slightly differently with absorbent material this column, causing different flow rates |
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| 09:31 | they flow different clips for the different and leading to the separation of these |
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| 09:37 | ingredients in the solid mix here as flow out of the column and then |
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| 09:44 | one as it flows out of the gets detected by this detector the waist |
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| 09:49 | discarded and the active fella must get by the detector. They get computerized |
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| 09:57 | presented as these peaks. Okay so is a principle behind behind high performance |
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| 10:04 | chromatography or liquid chromatography in general. more sophisticated techniques that have been developed |
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| 10:12 | . Why should you care about Because most of the time when you're |
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| 10:16 | about preparations, botanical preparations, that in pharma copia and Pharmacopeia was the |
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| 10:26 | of medicines, the substances and how use them for medicinal purposes. That |
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| 10:31 | present before there were other regulatory agencies were established such as Food and Drug |
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| 10:38 | which was only really formally taken its . Although the food substances different substances |
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| 10:47 | food and supplements were Starting to be from 1906. But formally food and |
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| 10:55 | administration and controlling the active ingredients in really didn't formalize until the 40s, |
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| 11:01 | , 60s and even 70's when it up with a certain schedule of |
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| 11:07 | So now what you have is most the preparations and the pharma copious were |
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| 11:15 | botanical extracts. So you can take route and you can take this plant |
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| 11:20 | you can take this leave and you soak it in alcohol and then you |
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| 11:25 | make this concoction. And so and there was H. P. |
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| 11:30 | C. And liquid chromatography techniques, really didn't have a good way to |
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| 11:37 | the molecules from these preparations and as know France and fruit and anything that |
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| 11:48 | natural mushrooms, lettuce vegetables also contain number of ingredients. And so we |
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| 11:58 | know what was the active ingredient really is causing in Canada's. We didn't |
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| 12:04 | what this active ingredient is that is this effect of of euphoria or the |
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| 12:11 | effect. Until After the h. . o. c. was developed |
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| 12:16 | the 1960s 1960 for Dr. Mateos isolates and correctly describes the primary |
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| 12:27 | ingredients and the cannabis plant, Delta Tetrahydrocannabinol or THC. Within about 20 |
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| 12:37 | there are two Delta 9 synthetic medications our pharmaceutical medications that are released Babylon |
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| 12:47 | the national. They're both 2.5 THC tablets that are used in the |
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| 12:54 | stimulation as empire medic as we refer . Last lecture in the wasting syndromes |
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| 13:01 | is quite common with chemotherapy and terminal . So the synthetic DELTA nine THC |
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| 13:09 | FDA Food and Drug administration approved preparations been around since 1980. Plant based |
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| 13:19 | nine THC And the second most prevalent cannabinoid that is found in Canada on |
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| 13:27 | came about only in 2005. So 50 years after the isolation of this |
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| 13:34 | nine THC molecule, the big Malls is actually a combination of 1 |
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| 13:41 | 1 THC. To CBD buckle spray it's a spray that you spray in |
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| 13:47 | cheek or underneath your tongue because most the absorption you have of active ingredients |
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| 13:53 | the oral cavity is in the cheek . Sublingual lee and in the upper |
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| 14:01 | where you have the best rates of of the active ingredient. So the |
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| 14:07 | Smalls is used for anti spasms. anti spasmodic or spastic activity and or |
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| 14:18 | in multiple tourism. But this drug um also it's not available in the |
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| 14:26 | States and all of the drugs that seeing in the slide or pharmaceutical of |
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| 14:33 | that are approved by F. A. And can be prescribed by |
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| 14:39 | qualified physicians. These are pharmaceutical cannabinoid . There are some panic And they're |
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| 14:48 | plant based but the victim also is available in the United States available. |
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| 14:52 | thinking about 25 different countries that originated the UK. It was quite available |
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| 14:59 | most of the european countries and beyond second plan days drug didn't see its |
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| 15:06 | and approval by the until 2016, was Cannabidiol, oral solution or a |
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| 15:16 | chur the drops that is mixed with seed oil, alcohol, strawberry |
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| 15:25 | Not really plasm or good preparation, I would not consider it. But |
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| 15:30 | has been tested and it is very as anti convulsive. Some meaning it |
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| 15:37 | seizures and especially the types of features are intractable for types of epilepsy is |
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| 15:47 | are intractable. Intractable means they cannot treated by readily available pharmaceutical medications and |
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| 15:56 | plant derived CBD helps in particular DR . And lemons get stopped syndrome upward |
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| 16:04 | . So it is now approved in United States On schedule five of the |
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| 16:11 | proof and can be prescribed been used anti convulsants. These are all of |
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| 16:18 | FDA approved medications in this country. really have dealt amount of THC and |
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| 16:25 | . You don't, there is no for THC and CBD preparation during the |
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| 16:34 | subsidize pharmaceutical war. If you get chance, I urge you to watch |
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| 16:40 | movie called the scientist, DR rafael scientists or was probably the only scientist |
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| 16:50 | want and confiscated hashish from the police in as well. And she's was |
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| 16:58 | confiscated by Israeli police and he wanted police and got himself the chunk and |
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| 17:03 | it in his bag and rode the and everybody was wondering the bus with |
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| 17:07 | smelling so much and he took it the lab and he isolated. Then |
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| 17:15 | found THC and many scientists have tried on themselves. So he then credit |
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| 17:22 | monkeys and in the lab and some got very active when you tried higher |
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| 17:30 | and playful and you tried higher doses THC they seem to have gotten a |
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| 17:35 | bit like sedated and may be So then he decided well let me |
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| 17:43 | some home. So he took it and had his wife, bacon, |
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| 17:49 | cake And he had eight guests over slices of chocolate cake. Each slice |
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| 17:56 | chocolate cake has 10 mg of THC , mind you, this is |
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| 18:01 | So they didn't know much about the dozing for humans. And the only |
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| 18:07 | he had was from this monkey So he has eight guests over. |
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| 18:12 | if you watch that movie, the , we have cake after dinner and |
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| 18:19 | of the guests are laughing their butts . I don't exactly remember the |
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| 18:25 | One of them is really kind of seemingly unchanged. The other one seems |
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| 18:30 | be fidgeting and was very busy and of the persons other people are having |
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| 18:36 | conversation and social and one person is a panic attack and so they calm |
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| 18:44 | person down from the panic attack. to this day, we know even |
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| 18:51 | on that very first anecdotal incidents with Meshulam and the chocolate cake. We |
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| 18:58 | that different individuals will react differently to and phenomenal and has to do with |
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| 19:07 | discussion we had at them of last . That was actually prompted by one |
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| 19:13 | the questions. And that discussion was the endocannabinoid system tone and what is |
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| 19:20 | endocannabinoid system tone is and how you measure it. And so there is |
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| 19:25 | differences in the levels of the endocannabinoid of an avenue receptor expression, even |
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| 19:32 | enzymes that synthesize or degrade. And there are enzymes, forests and the |
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| 19:39 | that would be degrading THC also after consume it as it gets into the |
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| 19:45 | . So all of these things depend an individual. Now for the most |
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| 19:50 | we know that it may have negative in about 10% of individuals. Sometimes |
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| 19:56 | negative effect. The first time use THC that is medicine, the recreation |
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| 20:02 | called the first pass effect. Whenever passes into your body it passes through |
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| 20:08 | body. First time you may have strong reaction. You know an equivalent |
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| 20:15 | is um for many people it happens coffee with caffeine they haven't had in |
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| 20:23 | law has a strong effect of nicotine smoking a cigarette after not smoking for |
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| 20:29 | while. I used to smoke when was younger would make me really dizzy |
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| 20:33 | almost nauseous. But then that was first pass. And then in the |
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| 20:37 | and 3rd cigarette seemed to be like . So that's what we're talking about |
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| 20:42 | you can watch more about the movie the further developments that were happening. |
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| 20:48 | Raphael Meshulam was still alive and is active in Israel and the research community |
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| 20:55 | very active and I've been connected, the pleasure of connecting with him and |
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| 21:01 | with him in person as well. this is the endocannabinoid system. And |
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| 21:11 | we already discussed that in the previous , this is just a reminder and |
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| 21:17 | are some of the different functions that modulate and regulate paying stress immune |
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| 21:23 | appetite member information, thermal regulation and the Canaveral and molecules such as anandamide |
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| 21:30 | Finnish, economical on fuel such as THC are very similar and live where |
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| 21:36 | can buy them. To see the . When you talk about cannabis |
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| 21:42 | you have to realize that most of cannabis products and most of the medicines |
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| 21:47 | general that you consume go through the ingestion and whenever it goes through an |
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| 21:53 | in josh o it gets absorbed. if you're tuning the swallowing and in |
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| 22:01 | if you're talking about cannabis, medical products that are available in the state |
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| 22:05 | texas, it is only these oral products and these topical minimum products that |
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| 22:11 | basically creams and south. So in best way to introduce exogenous cannabinoids into |
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| 22:22 | system, into the brain or the is through inhalation vaporization, which is |
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| 22:28 | lower temperature eating without burning plant matter a preferred way to smoking and the |
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| 22:35 | of inhalation into the bloodstream through the and the deal I can be immediate |
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| 22:42 | both the medicinal and adult use Now that is already in the |
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| 22:51 | Now, if you're talking about oral that can take 1/2 an hour to |
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| 22:58 | hour, sometimes even two hours because depends on each individual's metabolism, how |
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| 23:06 | the metabolism is, how fast is digestive system acting? It depends on |
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| 23:12 | prior history, what is in the justice system. So there's a delayed |
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| 23:19 | of ingesting cannabinoids and cannabis. It's prolonged the fact with oral and Joshua |
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| 23:28 | inhalation, that effect is typically half the time of the ingested effect, |
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| 23:33 | is 68 hours. Also when it in, just that it goes through |
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| 23:39 | secondary liver metabolism. Then you get and deliver of delta nine THC into |
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| 23:47 | 11 0. H. THC, also has both medicinal but also euphoric |
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| 23:54 | as well. Another good product that think when I talked about about everything |
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| 24:01 | this class about Alzheimer's and Alzheimer's medications think about what's needed, What may |
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| 24:07 | to be developed in the future, is accessible to be developed because I |
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| 24:12 | that my students like yourselves will be if not uh cannabinoid medication developments, |
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| 24:21 | in Alzheimer's medication developments or other um could leave all these functions that you |
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| 24:27 | find interesting. So suppository, for , is also another very good way |
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| 24:34 | getting cannabinoids into the system into the . You can have either anal or |
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| 24:42 | suppository and there's a lot of blood , there's a lot of sensitive nerve |
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| 24:50 | . So there's a lot of absorption these areas and the active ingredients get |
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| 24:56 | delivered into the bloodstream and you don't this secondary liver metabolism by that. |
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| 25:06 | these are all of the different things consider. When you're talking about products |
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| 25:12 | you're talking about pharmaceutical products, Sublingual, in fact these synthetic THC |
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| 25:22 | are um not regarded very highly by . A lot of the patients prefer |
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| 25:29 | switch to plan the right preparations go back a little bit two basics |
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| 25:34 | understand what is legal. It is , for example, in this |
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| 25:40 | low THC cannabis is also referred to hemp for industrial, it's typically Canada |
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| 25:49 | , which is a subdivision of which is sativa, indica hybrids and |
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| 25:55 | Morales with most of the Canada strengths help. And even in high THC |
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| 26:01 | such as medical cannabis, recreational adult cannabis as a birth way. Most |
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| 26:06 | them are hybrids and mixed sativa and . It's and Morales given together. |
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| 26:12 | most of the hemp that you have in this country that is legal is |
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| 26:19 | THC and the plant matter. These typically tall plants, but they can |
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| 26:24 | be grown shorter depending on the purpose the tall plants. They can be |
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| 26:28 | for their stock for the seeds and you're using it for the seeds and |
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| 26:33 | using growing male plants And those seeds very nutritional and you can make oil |
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| 26:39 | of these seeds that doesn't have much a cannabinoids and can be used as |
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| 26:44 | great food source from the great source omega three omega six um fatty acids |
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| 26:52 | the cut off or legal Federally So even in Texas, you can |
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| 26:57 | $150 as a farmer and you can hemp seeds and grow hemp seeds as |
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| 27:02 | as you're teach sea level that the sea level is going to be below |
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| 27:08 | . However, in natural circumstances and to teach the percentage of the levels |
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| 27:16 | other cannabinoids and other molecules in the very much dependent on the local fluctuations |
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| 27:23 | the weather and local fluctuations in the of light, division, temperature and |
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| 27:30 | in the soil. And sometimes these come plans. They peak Th C |
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| 27:36 | was about 0.3%. And naturally these what we would consider industrial home |
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| 27:44 | They can actually go up to almost to 1% of THC. And |
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| 27:51 | level of THC is also the level THC that can be present and finished |
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| 27:57 | from investment. Uh these levels like , It's legal in Italy and is |
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| 28:07 | considered industrial health 1% THC is still an industrial hemp in Czech Republic, |
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| 28:14 | still considered industrial sample 1%. In . So you have different international entities |
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| 28:22 | governments setting this natural plant the limit THC what is allowed and what is |
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| 28:27 | him, but it's not the United is 0.3% THC high THC cannabis is |
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| 28:35 | grown for female plans that have these color was also reported as buds and |
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| 28:43 | are for medical cannabis for recreational muslim or hybrids and THC levels. |
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| 28:50 | these plants that you will typically goes anywhere between 5 to 25% THC |
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| 28:57 | what it's called. High THC you , the highest THC levels are the |
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| 29:02 | Level of cannabinoids that these plants can is about 36%. So that means |
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| 29:10 | 36% of genetic material and everything you in those big cola would be dolphin |
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| 29:16 | THC so this is very very And in general it's a total amount |
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| 29:22 | cannabinoid. It's not just THC that be peaking at about 36%. These |
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| 29:28 | usually shorter plans traditionally because of the activity and illegal growth that was growing |
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| 29:35 | . No, because of legal And so many states including medical Canada's |
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| 29:40 | texas. There was a variety of , stocky short plants and that that |
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| 29:47 | that long to find he would often this term synthetic or street cannabinoids and |
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| 29:55 | marijuana or synthetic cannabis. Just think that there is synthetic anonymous. But |
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| 30:00 | think if there is synthetic marijuana, synthetic cannabis. If you think this |
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| 30:09 | isn't such a wrong term to use marijuana, it's like saying there's a |
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| 30:14 | um orange, there is a synthetic , there is a synthetic rose, |
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| 30:24 | an element from that melon, but not a synthetic melon. Have you |
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| 30:27 | one? I have virtually only but doesn't exist When we talk about synthetic |
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| 30:36 | that are listed. They're synthetic in . It's not cannabis. They're |
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| 30:43 | They're fake. They're usually synthesized in lives in Eastern europe and asia and |
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| 30:51 | horrible places to do that kind of . They're really potent powder like materials |
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| 30:57 | are sprinkled on the plant like matter in different packages from the kush spies |
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| 31:04 | sold their headshots and the regulators kind chase them fast enough because There's over |
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| 31:12 | actually did research with one of the students published a really Interesting article just |
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| 31:19 | popular literature, synthetic anomalies, over variants that were reported and that was |
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| 31:27 | years ago. And so they get on some plant matter tobacco Matter packaged |
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| 31:34 | shipped and sold them head shops and removed and then some other shipment comes |
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| 31:38 | with some other molecule and turns out be the synthetic anatomy. So is |
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| 31:43 | worse in Houston and Hermann Park, so far from where you are. |
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| 31:50 | you're on campus or if you live campus There were over two dozen deaths |
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| 31:57 | occurred because somebody was dealing synthetic anonymous cannabinoids are so dangerous that one use |
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| 32:13 | psychosis and can cause even chronic psychiatric . One use and overdoses are quite |
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| 32:27 | and intoxication are possible as well as that are not legal in our dragons |
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| 32:34 | this is different parts of cannabis plants leaves and stems. You have |
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| 32:44 | These flowers will have these uh huh . The balloons will contain these grandeur |
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| 32:53 | combs that are semi translucent, that contain cannabinoids and also will contain terrapins |
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| 33:01 | up to 60% cannabinoids in these strike and up to 8% of these Turpin's |
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| 33:07 | are aromatic molecules and the molecules that we smell. Canada's you have |
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| 33:15 | I have seen sprouts and all of different parts of the plan especially when |
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| 33:21 | talk about hemp plants that are grown long stocks can be used for different |
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| 33:28 | . Even the roots, the roots try turbine oil alkaloids and the roots |
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| 33:34 | used by historically, by this an greek and ancient Greece to make concoctions |
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| 33:46 | roots to treat information, cannabis it stems can be purposed into fiber |
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| 33:55 | ropes. And if you wonder what the ropes made out of before? |
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| 34:02 | were synthetic material before there was cotton example there was ham probes, probes |
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| 34:11 | all the way to the middle of 20th century when there was no more |
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| 34:15 | . Ah that's how plastics it can made from the plant from the seeds |
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| 34:23 | oil. The central fatty acids 35 up the seed sprouts will have this |
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| 34:34 | play them. And when we talked emergent were we born plants in this |
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| 34:44 | the plants that we are allowing again as the hand plans to be federally |
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| 34:49 | and drawn again you have to think all of these different aspects and |
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| 34:56 | When people think about cannabis and they about Hampus THC CBD. I think |
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| 35:02 | the harpers house socks, food and inflammatory properties of course, cannabinoids promoting |
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| 35:13 | wellness, sleep scorpions, nice Okay, so there's very different applications |
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| 35:21 | in emerging markets that form around plants are being reintroduced back into societies |
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| 35:29 | It's different and marginal markets can these parts of the plant targeting different |
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| 35:37 | different, completely different industries from nutraceutical . Two industrial engineering in the building |
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| 35:47 | , which is really, really interesting it's a very durable building material |
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| 35:55 | if you basically chop up ham stems mix them with lime and water, |
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| 36:02 | becomes a fantastic building material. Work and installations. Okay, so we |
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| 36:13 | into the tri cones. That's what tri cones look like. There's a |
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| 36:19 | , they have a whole biochemical machinery the top of their heads that synthesized |
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| 36:26 | . Roids. And the whole cellular supporting the head of the traffic cones |
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| 36:31 | they come in different shapes and different . They're typically under 100 or 150 |
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| 36:37 | and life or so. And there a central droplet metabolite droplet that is |
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| 36:46 | in the head of these tri cones that's what you have cannabinoid synthesis and |
|
| 36:51 | cannabinoid synthesis will synthesized cannabinoids. And also have disc cells here that will |
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| 37:00 | producing Turpin producing cannabinoids intermediates and recently it's important because Turpin's besides being volatile |
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| 37:13 | and smell the aroma giving molecules to plants also can be precursors to |
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| 37:19 | And some of these serpents are also be magnetic. That means that they |
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| 37:24 | activity of some kanab. So you the federalist structure here. You have |
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| 37:32 | structure of the citation here for the the for the article, the major |
|
| 37:41 | . When we talk about cannabis are that's what everybody talks about. First |
|
| 37:48 | CBD now everybody talks about CBD uh Fox News I think talks about Pe |
|
| 37:54 | na. It's everywhere and C B or C B. G. And |
|
| 38:00 | general, where do these bananas come ? Well, first of all, |
|
| 38:05 | have to be synthesized by the plans we're talking about vital economic policies around |
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| 38:10 | phenomenons synthesized by the plans. The B G A is the root or |
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| 38:18 | mother of C B C B D N T H C A. And |
|
| 38:25 | are these CBD and THC a. plant cannabis plants has seven cases that |
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| 38:33 | the Civic versions of delta nine, a. Tetra hydro phenomenology or C |
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| 38:42 | G. A canopy Jiranek C B A C B D. A sentence |
|
| 38:49 | C B G A, which is core molecule, THC a sentence will |
|
| 38:54 | it into Hc A CBD a Alternative C B D. A. |
|
| 38:57 | is kind of a dialect cost. the plan actually doesn't even produce THC |
|
| 39:05 | doesn't synthesize to you. Only synthesizes Civic versions of THC CBD CBD the |
|
| 39:18 | versions which is THC or CBD and they become neutral versions through heating process |
|
| 39:28 | otherwise. The chemical decoder box elation . When the Citigroup is removed, |
|
| 39:34 | acid group is removed from THC A nine and it becomes delta nine |
|
| 39:41 | The same happens with C. G. A. From CVG through |
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| 39:45 | letterbox elation, CBD A becomes CBD the car box elation as well. |
|
| 39:51 | this plant actually that is viewed And molecule cannabis plant is viewed as the |
|
| 39:59 | stringent federally controlled, planned and scheduled the same as heroin that plan. |
|
| 40:07 | it's schedule one. And the federal says that plant is because it contains |
|
| 40:16 | In reality that plan doesn't continue, THC you know if you heat plant |
|
| 40:24 | vaporizing it or smoking it or heating . Otherwise it will turn into |
|
| 40:30 | But the plant itself doesn't contain So it's on schedule one or some |
|
| 40:36 | reason because of the default box Now we talked about CB one receptor |
|
| 40:43 | what a fact CB one receptor has neuronal transmission. We talked about. |
|
| 40:49 | . Burgess and with dramaturgical neural transmission . And now we can understand that |
|
| 40:54 | example THC just like anandamide or to G. Um Other than economical it |
|
| 41:02 | be an agonist Two CB one That means that when it binds to |
|
| 41:06 | one receptor would activate the G protein . That would block the calcium |
|
| 41:13 | C. B. G. Which also found of plans will also bind |
|
| 41:17 | CB one receptors but it can activate one of the South course is an |
|
| 41:23 | with CB one or something. and Dampens CB one activity when it binds |
|
| 41:29 | CB one receptor, it is called Alistair IQ modulator. So it will |
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| 41:37 | Dampen The Activity of CB one And so now you understand that the |
|
| 41:43 | , Canada's plant will contain a variety these phenomenal is and this is just |
|
| 41:47 | of them that are major ones that discussing. In reality. There's over |
|
| 41:52 | different phyto cannabinoids from Canada's plant. are the major phyto cannabinoids. There's |
|
| 41:59 | lot of minor phyto cannabinoids that are that come in small quantities and hard |
|
| 42:04 | find. But they do exist And you can see that these three major |
|
| 42:10 | Canavan on THC CBD and CBD are different relationship, not different completely but |
|
| 42:18 | relationships And regulating or modulating CB one . If you look at the final |
|
| 42:27 | in excess of 115 I think maybe over 120 turbines, I think it's |
|
| 42:33 | over 140 turbines that are found in . If you look at the literature |
|
| 42:39 | I'm not talking about the conditions and FDA has THC approved for. But |
|
| 42:45 | you look in the literature, do see causes the high effect on psychotropic |
|
| 42:51 | is known but it is also anti . And you're a protective. In |
|
| 42:55 | if you search us government patent on neural protection, you will get the |
|
| 43:02 | . S. Government patented patented for inflammatory and Europa tec tive purposes. |
|
| 43:07 | analgesic, it helps from pain. know that we saw that the FDA |
|
| 43:11 | appetite stimulant of course anti climatic prevents anticancer. Does that mean it is |
|
| 43:21 | cancer litigation? No, but there significant evidence showing that it can stop |
|
| 43:29 | of cancer cells. A lot of has been done in vitro and a |
|
| 43:33 | of it has been done with synthetic that you can use in the lab |
|
| 43:38 | THC but robert plant derived molecules. I think that evidence is mounting as |
|
| 43:44 | . There are negative side effects of can cause anxiety and panic attacks. |
|
| 43:49 | can increase and raise the heart. hard trade has low rate of |
|
| 43:55 | So we talk about cannabis addiction or . It's not only just THC because |
|
| 44:06 | example, I'll give you an example what you crave for when you go |
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| 44:12 | take a shower and you have your shampoo or body wash or body lotion |
|
| 44:20 | you put after the shower. Why crave it. You crave the |
|
| 44:24 | You don't necessarily crave. Oh, going to have such moisturizing a fight |
|
| 44:29 | you crave the smile. So you dependent on having a good experience partly |
|
| 44:39 | you have a small presentation that's very sensory sensation. So this dependency is |
|
| 44:46 | not linked to CBD. CBD. can actually be anti addiction. CBD |
|
| 44:53 | been shown in studies to reduce addiction to opioids. So but there's low |
|
| 45:01 | one in 11 people that have cannabis disorder that typically functional members of the |
|
| 45:09 | but they overuse cannabis priorities cannabis and functionality and that dependency as I said |
|
| 45:22 | low rate and even lower number of would have hyperemesis syndrome which is this |
|
| 45:30 | indigestion and very strong abdominal pains typically the morning that are linked to high |
|
| 45:36 | of THC US and potentially some genetic uh alterations or that a person may |
|
| 45:45 | predispositions. CBD has been shown to non non psychotropic, meaning it doesn't |
|
| 45:52 | a high effect and reduces not gonna with THC it's actually antisocial coding and |
|
| 45:59 | neural protective and by cancer is not diabetic contradiction and geopolitical combust into american |
|
| 46:05 | cheesy. Does that mean that CBD FDA approved for these conditions now. |
|
| 46:11 | there is ample evidence if you look search for both animal and human studies |
|
| 46:18 | of them are placebo double, why controlled others are survey studies, others |
|
| 46:23 | randomized studies of small cohorts of patients will find the effects of CBD. |
|
| 46:30 | these conditions it has mild side effects just fatigue drowsiness and high levels of |
|
| 46:36 | . And some people can call in and causing digestion high levels of cannabinoids |
|
| 46:42 | CBD and CBD and other cannabinoids also have a drug and drug interaction that |
|
| 46:49 | person is taking another drug for treating condition. C B. G. |
|
| 46:54 | know that C B G is a one antagonist. It's a partial agonist |
|
| 46:59 | CB two but it also binds to other receptors serotonin and trp and transient |
|
| 47:06 | potential receptors. It can increase under . Okay, it also interacts with |
|
| 47:15 | are gamma and healthy to enter energetic experientially. There isn't enough evidence of |
|
| 47:21 | B. G. There's I believe one clinical trial experimentally. Cdbg seems |
|
| 47:26 | be beneficial and used for anxiety treating and sleep negative effects of THC as |
|
| 47:36 | . We call the THC CBD and may act via the same or different |
|
| 47:42 | . This is this is the CBD to serotonin receptors. Yes. |
|
| 47:47 | Actually CBD prefers to mind to serotonin over the canal. Did she also |
|
| 47:54 | the trip receptors. So these five molecules, when we're talking about the |
|
| 48:01 | system where being kind of the CB centric but this shows you that this |
|
| 48:06 | will also be other the neurochemical and receptor systems in the brain and the |
|
| 48:15 | you call that this is all that approved by FDA that if THC replying |
|
| 48:22 | DVD in this country talked about that substantial evidence of cannabis and cannabinoids have |
|
| 48:29 | this the last time and effective for , nausea, vomiting, Multiple multiple |
|
| 48:36 | , spasticity. There is moderate evidence this is from 2000 17. And |
|
| 48:40 | can read about limited evidence that exists cannabinoids for different conditions like glaucoma for |
|
| 48:48 | . But it's a little bit, never does. And maybe some of |
|
| 48:52 | studies that were done improving inter ocular is maybe not the only thing that |
|
| 48:57 | should be looking in glaucoma. Uh we may be looking at the reduction |
|
| 49:02 | information. And that's something that the is agreeing to start using phenomenal is |
|
| 49:07 | for ocular inflammatory symptoms. Now when talk about what is legal, what |
|
| 49:15 | made in the plan of what is by humans? I already showed you |
|
| 49:20 | there is C. B. A. Sent a S. And |
|
| 49:24 | CBD a synthesis or CBD that's produced the form. I showed you that |
|
| 49:30 | is delta nine THC a synthesis and nine is produced by the plan by |
|
| 49:41 | . And I also am showing this to which is delta eight THC. |
|
| 49:50 | in this ring here, at the left you have the number of carbons |
|
| 49:58 | nine term. So delta nine THC have a double bond between the line |
|
| 50:05 | 10 Delta 80 C. Will have bond moved over between eight and |
|
| 50:13 | The plan's the only thing you always to balance. I have to ask |
|
| 50:20 | you're talking about an avenue is the or in fact if you're talking about |
|
| 50:26 | and carrots, is is there synthesis molecules And if the answer is |
|
| 50:33 | that means it doesn't come directly from plant. It takes another process than |
|
| 50:40 | simple decoder box elation and such is case with delta eight THC, which |
|
| 50:46 | medium binding properties to see the one can cause half of the euphoria high |
|
| 50:52 | . And there's no known medicinal properties doubt the THC. I can tell |
|
| 50:59 | if you want to learn more. give you a link to read one |
|
| 51:03 | my articles about delta eight THC that all of the references. But there's |
|
| 51:07 | lot of additional evidence for CBD. lot of additional evidence for delta |
|
| 51:12 | But there isn't Many for Delta eight Delta eight comes from CBD. So |
|
| 51:19 | you have the CBD molecule to the box elation, you actually have to |
|
| 51:24 | a chemical manipulation of CBD so that get this DELTA A. You get |
|
| 51:32 | bond and the desired location on this . And it's not a very necessarily |
|
| 51:39 | procedure. It's another chemical procedure. there's a lot of unknowns with delta |
|
| 51:44 | THC but you will see it advertised heavily and the current state is not |
|
| 51:51 | controlled by the texas regulators. That's is being advertised with a lot of |
|
| 51:56 | shops and shops and such, you , just cautionary. No, I |
|
| 52:01 | know much doesn't come from the That means that different labs will use |
|
| 52:07 | methods, temperatures solvents and such to to where they need to get This |
|
| 52:15 | in respect of the binding properties to one receptor. I hope you appreciate |
|
| 52:20 | creativity. This is actually somebody asked about my company. This is one |
|
| 52:25 | the adventures and involved in Canada's Bluebonnet wellness and you can see the |
|
| 52:33 | flower here on top of the bonnet um Canada's leads here at the bottom |
|
| 52:42 | any case, Canada squad as I , will produce a whole bunch of |
|
| 52:47 | Canavan ours and Turpin's THC CBD CBD bc Canada Korovin, C B M |
|
| 52:56 | D D V. Canada environment. like I said over 120 or so |
|
| 53:02 | cannabinoids that are produced in different varieties would be called different strains of cannabis |
|
| 53:11 | . Turpin's is what Canada's prime But Turpin's can be found in |
|
| 53:18 | the Lyman E will be found in and orange and mandarin and Canada's |
|
| 53:24 | And those tri cones will produce a of Lyman is one of the most |
|
| 53:28 | . Turkey's can have 1 to 2% Lyman in and the total mass of |
|
| 53:33 | tri cone which is really significant. cannabis will smell like commons. Carrier |
|
| 53:39 | in the baby carrier film was most european that is expressed and hound and |
|
| 53:47 | cannabis molecules and in fact when dogs used to drug dogs used to sniff |
|
| 53:53 | cannabis. They were trained to sniff carrier film just carry a film. |
|
| 53:57 | more volatile. It's too big because present in cannabis plant but it will |
|
| 54:02 | be present. And cloves and Um Black peppers and then particularly this |
|
| 54:10 | pepper from West africa that has very levels of mercury offline Very very often |
|
| 54:16 | out to be a selected CB two agonist. Whoa. It's a |
|
| 54:21 | dramatic periodical and this Canada pneumatic molecule pneumatic appropriate that acts sort of like |
|
| 54:28 | and interacts with CB2 receptors. Another common topi ating is lying a little |
|
| 54:37 | Lionel would be found alive under. if the same try cones that we |
|
| 54:42 | about instead of expressing Lyman. Mean would be expressing line a little turkey |
|
| 54:47 | the cannabis plants would smell like There's many different smells and some Canada's |
|
| 54:53 | smell like gas that have very earthy gassy smells. And that's because different |
|
| 55:00 | of cannabis plants depending on the depending on the growing conditions, the |
|
| 55:08 | time, the curing preparation of the product from the plant matter, whether |
|
| 55:15 | oil or gummy or something else. plays into the final composition, what |
|
| 55:24 | call them matrix but the active elements ingredients that these products will contain. |
|
| 55:31 | it may be biased towards each seat be biased towards CBD may be biased |
|
| 55:36 | lima beans. But in reality any of the botanical preparations will gain dozens |
|
| 55:43 | active ingredients and dozens of active ingredients even more. But at least dozens |
|
| 55:49 | active ingredients that have known biological properties have known physiological effects on our |
|
| 55:58 | And why the little, for example very known common properties of lavender. |
|
| 56:05 | hmm. So why my name Lionel lavenders, anxiety, litigant and |
|
| 56:15 | And the combustion analgesic alpha pioneer acts as some falco monasteries inhibitor. If |
|
| 56:23 | recall as of alcohol investors breaks down single colon molecules in the synapses and |
|
| 56:30 | a table column mysteries, inhibitors, will actually learn about it more when |
|
| 56:35 | are studying Alzheimer's disease for those that taken by force. But the most |
|
| 56:41 | Alzheimer's medications are actually alcohol industries So alpha pining which is found in |
|
| 56:49 | lot of the difference plans and and some in some cultures in japan for |
|
| 56:58 | , there is what is called forest and that is walking through the forest |
|
| 57:05 | has a lot of these pipeline like because there will be smelling very strong |
|
| 57:13 | it has very strong relaxing properties. at the same time with access that's |
|
| 57:18 | topical administration inhibitor, it is It could reach its systemic Marceline Marceline |
|
| 57:28 | farm and mangoes very common from It's also firemen and cops. |
|
| 57:36 | and when you talk about hops, interesting is hops is the closest plants |
|
| 57:44 | Canada. Mhm. A they're the related plants hops and cannabis, the |
|
| 57:53 | are of course used to make a of things. But a lot of |
|
| 57:58 | that we like that comes from the is called beer and hops you know |
|
| 58:05 | like an avenue noise can have you for example if you are showing me |
|
| 58:13 | but if you go and if you drinking beer next time maybe you should |
|
| 58:18 | attention to with hops we used and will see things like I'll tell you |
|
| 58:25 | hops, what is Citra hops gonna you think about? Probably citrus but |
|
| 58:30 | what? Citra hops are likely to aromatic Turpin's that are resemblance of the |
|
| 58:39 | that you will find in citrus such why money deal. So they have |
|
| 58:46 | own biological they also have their own properties. That's why you need |
|
| 58:54 | L. C. You need to your botanical preparations, analyze them the |
|
| 58:59 | output of active ingredients, the ratios concentrations. And that will lead us |
|
| 59:04 | more sophisticated formulations that we could then into pharmaceutical drugs as well. But |
|
| 59:12 | now we have a variety of different Canada's and when I say legal |
|
| 59:19 | legal cannabis THC systems. Most of countries in the world except for Russia |
|
| 59:26 | Russia will probably never legalize even In fact one of their pieces of |
|
| 59:33 | is that Ukrainians dressed some of the on earth. Um They don't like |
|
| 59:41 | but let me not get off the here and get very very angry. |
|
| 59:46 | will turn very very red and probably if I stay on this topic any |
|
| 59:53 | with concerns the dictators and tyrants that unfortunately murder and gas Children. So |
|
| 60:04 | talk about what actually could help the soldiers and what could help the Ukrainian |
|
| 60:12 | to recover. One of those things would argue would be phenomenal in particular |
|
| 60:18 | from THC. And globally you have legal cannabis systems. So you have |
|
| 60:24 | pharmaceutical system which is the National So some of the drugs like Marinol |
|
| 60:30 | the United States, the Activex has is CBD THC plant derived has approved |
|
| 60:35 | the U. K. But it's approved in the United States. And |
|
| 60:37 | you have some drugs like At the which is 20% CBD approved in the |
|
| 60:43 | and approved in the United States and in different schedules in these countries. |
|
| 60:48 | are health insurance subsidized medical cannabis They also have national and also you |
|
| 60:55 | say international because there's shipments that are of Canada's between different countries such as |
|
| 61:01 | Colombia and Germany and Portugal and Germany South Africa and other places and |
|
| 61:09 | So these are international nationals. National medical cannabis programs example is Germany |
|
| 61:16 | Canada's flowers sold in pharmacies and his insurance subsidies in the United States and |
|
| 61:22 | have states regulated cannabis programs in some they have both medical cannabis programs and |
|
| 61:31 | or adult use medical cannabis or adult cannabis programs that are not medical. |
|
| 61:37 | an example is the state of massachusetts has both a very robust medical cannabis |
|
| 61:44 | and recreationally program. In this the patients that are registered medical cannabis |
|
| 61:52 | , They get tax exemptions, but health insurance does not cover any of |
|
| 61:58 | state regulated cannabis products, so far there's a 20% tax exemption in states |
|
| 62:05 | Massachusetts, that means that they don't 20% tax that recreationally user in massachusetts |
|
| 62:12 | the state has both programs would pay recreational adult use programs. Our neighboring |
|
| 62:20 | of colorado, our neighboring state of has a very robust medical program. |
|
| 62:28 | Mexico is moving into recreational programs. Oklahoma Louisiana has a pretty robust medical |
|
| 62:37 | . But you have developed these programs by state, California is probably the |
|
| 62:42 | state in the economy and the fifth economy in the world that has legalized |
|
| 62:49 | use. Canada's has full taxation and specific. When you talk about Canada's |
|
| 62:55 | specific. So in one problems like on the uh, from the east |
|
| 63:02 | Canada, the dispensaries or the medical recreational Canada stores are going to be |
|
| 63:09 | by governments and monopolized by governments and you go to the west coast to |
|
| 63:17 | , Vancouver on the west coast of Columbia and you have dispensaries instead of |
|
| 63:24 | government run stores and you have consumption , all sorts of different programs and |
|
| 63:31 | problems that's in this case in Canada the United States is texas right now |
|
| 63:37 | have low THC and CBD. So have legal home program, we have |
|
| 63:42 | home products and then we have this THC medical cannabis products. Most of |
|
| 63:49 | things that we have in texas are products from extinctions. Large adjustment |
|
| 63:55 | ice cream, etcetera can also be ingestible difficulty of those is about 20 |
|
| 64:02 | . Um for some people it's five , some people, that's why it |
|
| 64:08 | up to 20 mg. So when Nahshon gave all of his friends 10 |
|
| 64:15 | and a piece of cake that was right, hundreds of milligrams of product |
|
| 64:20 | it can be used in extreme cases there is a severe condition or if |
|
| 64:25 | isn't enough stimulation of the cannabinoid system it may be. When you talk |
|
| 64:30 | ratios, we typically talk about ratios dominant cannabinoids and profits such as THC |
|
| 64:37 | CBD 1 to 1 versus 4 to 40 mg 10 mg of CBD per |
|
| 64:44 | . That's what we talked about. are the products all of the injection |
|
| 64:48 | that are available in texas. When talk about texas and in general texas |
|
| 64:57 | and in general any market cannabis products now have no standard. So you |
|
| 65:06 | potentially walk in to get some hemp from one store And you asked one |
|
| 65:13 | About CBD or CBD. And you one answer and then you'll ask them |
|
| 65:17 | the question. And the person will , I don't know. Uh and |
|
| 65:22 | they will recommend this, my grandmother this adults her and you're also about |
|
| 65:27 | see, well, you know, told me that the strain that's called |
|
| 65:30 | Dream is going to make your you want to try, it |
|
| 65:34 | you know, so it's all and . But I have a standard, |
|
| 65:38 | fact most of the products, we even have the proper active ingredients |
|
| 65:43 | they wouldn't even track these major Turpin's many instances that I just showed you |
|
| 65:49 | the reputed and biological effects, but interact with kannapolis and the interactions with |
|
| 65:55 | kannapolis and turbines is referred to as end entourage of facts, the entourage |
|
| 66:02 | the matrix of molecules and some of molecules will form an entire garage that |
|
| 66:09 | exemplify or exaggerate one effect or an theorized that will be competing sets of |
|
| 66:17 | and therefore not achieving the same therapeutic . Uh, when you talk about |
|
| 66:23 | cannabis and what can be done in journal in Canada spark is you have |
|
| 66:27 | realize that there's a lot of businesses texas, there's texas, compassionate use |
|
| 66:34 | , there's two licenses, there's a that pops up here in Houston but |
|
| 66:39 | focused in the boston area, There's 20,000 registered patients in Texas With 3-5 |
|
| 66:46 | , there's going to be about 800,000 a million registered medical cannabis patients in |
|
| 66:52 | . And so this is going to . But often get a question from |
|
| 66:57 | . Well, you know, I skills and I thi I have skills |
|
| 67:02 | programming. I work with scr stuff that's a Canada's industry now is a |
|
| 67:10 | , multi, multi billion dollar In fact right now, there are |
|
| 67:15 | , this company here called Duchy Within year duchy from zero became an evaluation |
|
| 67:23 | was the $4 billion valuation. And do these companies do that actually create |
|
| 67:31 | that solve the product and deliver the that identify the products. And that's |
|
| 67:36 | of the things that I'm working on actually how can we have the market |
|
| 67:43 | all of these products based on the ingredients is their system that would allow |
|
| 67:49 | to simply identify them probably based on active ingredients. You know why? |
|
| 67:54 | typically you don't really care much about when you shop for something specific. |
|
| 67:59 | always use beer as an example. love beer. But the reason why |
|
| 68:03 | love uh reasons many reasons why I beer. But the reason why use |
|
| 68:08 | for example is because if you walk to the isle that has microbrewery |
|
| 68:13 | it's the same thing. I don't . You just choose things by the |
|
| 68:17 | . If you know, pilsener versus versus queen ale vs. India pale |
|
| 68:28 | , That's good. Most of the don't, most of the people know |
|
| 68:32 | name the brand and that's all. you get bored with it and then |
|
| 68:38 | try something. Oh that didn't taste because you don't know what is in |
|
| 68:41 | ? You don't see any identifiable, you any active ingredient and you |
|
| 68:46 | beer, you can think it's a version when people consume cannabis, they |
|
| 68:51 | THC the consumer adam also can get pretty high. They don't see what's |
|
| 68:59 | the products and they don't have an way to another practice in the |
|
| 69:03 | So often people go on one trip colorado, they say kind of that |
|
| 69:07 | awesome. You know, I tried product and it relaxed me and I |
|
| 69:12 | asleep, I laughed and I then go back and they don't know how |
|
| 69:16 | find the same product because they cannot the same brand of Miller lite that |
|
| 69:21 | stolen every gas station so they can the same product. So was this |
|
| 69:28 | brand? I think there was. if the consumer just had an easy |
|
| 69:32 | to see some color, some picture strengthen the product, that's all they |
|
| 69:36 | to know. And right now, of the cannabis products are all kind |
|
| 69:41 | grouped together, there's no categorization and no standardization so that there is an |
|
| 69:47 | standard group that's working, we'll give another example. Again, they use |
|
| 69:53 | because alcohol has psychotropic or intoxicating Just like THC does imagine if you |
|
| 70:00 | in a total wine, which is big or specs or even in the |
|
| 70:07 | store and all of the Deers, of the wines, all of the |
|
| 70:12 | were mixed together. And what if saw brands that made liquor, beer |
|
| 70:21 | wine, have you seen corona Have you seen corona vodka And in |
|
| 70:28 | industry that exists you will see a that makes 15 different products from powders |
|
| 70:34 | drinkable als to smoke herbals to something to creams. And this is really |
|
| 70:41 | for the consumer and that's why I to educate you guys because I feel |
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| 70:45 | you're not only going to learn but can be smarter with this, not |
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| 70:50 | about Canada's but about anything beer. example when you next time choose, |
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| 70:57 | you know it's Citra hops that I because it has that lemony taste I |
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| 71:02 | knew and now you're gonna say I'm look for cetera hop but you're gonna |
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| 71:07 | back to that beer. I always where can I find Citra hops? |
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| 71:10 | no way that this beer is organized and flavors of strength and so maybe |
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| 71:16 | coming in the future too. But think there's a lot more sensitive because |
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| 71:21 | is still illegal in many places, still very highly regulated where it is |
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| 71:27 | and it is still has very high causing effect of properties. So |
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| 71:33 | really need to be more cautious and more attention to what is in the |
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| 71:37 | ingredients. So in texas, welcome taxes, welcome to texas. Here |
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| 71:44 | are now in texas and guess who in charge of the THC limit and |
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| 71:53 | is administering the medical cannabis program that not. Which is known as texas |
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| 72:00 | abuse program. You guessed the tribe and Human Services, no Department of |
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| 72:11 | Safety GPS, the Department of Public . You get you see state |
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| 72:21 | So it's DPS that has been charged regulating the program. There are two |
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| 72:26 | that allow for two companies right now grow th c up to 1%. |
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| 72:33 | the products reality, it's the limit 1% which is 10 mg of THC |
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| 72:40 | and hemp Farm bill which is concerns of hamp allows three mg of THC |
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| 72:46 | because it's 0.3%. And that's why texas program was referred to as Low |
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| 72:52 | program. And most of the other that you saw on the map |
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| 72:57 | these programs that are dolphin Medical used programs in dark green or comprehensive medical |
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| 73:04 | programs in light green and sharp, green. Those have very robust medical |
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| 73:12 | programs that have a lot of licenses a lot of products that are available |
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| 73:17 | they do not limit THC to There's no limit on THC, there's |
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| 73:24 | limit on the doses per serving in but there's no limit on THC and |
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| 73:31 | special inhalable products or flour products if may, the second component that's very |
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| 73:38 | component. But again, it should very interesting for you because I've talked |
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| 73:42 | it last time and said it is demonization of cannabis that I just showed |
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| 73:49 | with this reform madness. And how not only americans but cultures around the |
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| 73:54 | still think about cannabis is gateway drugs prophecies. Crazy drugs dangerous. You |
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| 74:00 | the benefits outweigh the hearts. We determined that all of these texas This |
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| 74:07 | state Oklahoma is the most conservative I think one in 20 individuals in |
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| 74:12 | is THC high THC cannabis. So not about being liberal being concerned. |
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| 74:21 | nothing to do about partisanship of Is it is it medicinal? Is |
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| 74:29 | dangerous or not? Answer is it medicinal? We need to know a |
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| 74:33 | more about it. There was a systematic as it was prohibition on |
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| 74:38 | There's a systematic suppression on the research could be done in Canada's plant, |
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| 74:43 | only changed last year until last There was only one facility in Old |
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| 74:53 | that allowed to grow candidates and that flower was really poor quality was |
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| 75:00 | did not have a variety of strains are available for the patients around different |
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| 75:05 | and it will solve the National Institute Drug abuse neither for research purposes. |
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| 75:11 | , curiously enough, it was sent pre rolled joints to several patients that |
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| 75:17 | access to to free medical Canada's because want hustles against Carolina. It's really |
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| 75:26 | things that, that, that you when you do a lot more research |
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| 75:30 | these things. So, but what really interesting is that there was a |
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| 75:35 | of the research and actual Canada's So you can go ahead and order |
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| 75:38 | synthetic THC $60 a monogram and do in the dish. Whole animal |
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| 75:47 | That's really difficult. But it's still planned research. And well, you |
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| 75:51 | to wait to get some molded powder Mississippi for about a year of junk |
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| 75:58 | and being under a microscope. And gonna think that you're going to intoxicate |
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| 76:03 | in the university or the hospital. you're near like a criminal, this |
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| 76:10 | all existed until last year. You believe you did research on Canada's |
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| 76:14 | Note that medical marijuana, medical there's existence in the state of California |
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| 76:26 | never dying. Piece. That's 25 years ago. It was legal. |
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| 76:37 | means the patients were buying it. using. But you could not do |
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| 76:44 | jobs. And until last year, still cannot do research from the dispensaries |
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| 76:49 | the weed marijuana, cannabis, whatever you wanna call it wherever you |
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| 76:55 | it in any dispensaries in massachusetts. cannot take it to the hospital, |
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| 76:59 | cannot take it to the university and research. As of last year, |
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| 77:04 | federal government allowed 11 more grows in to go through this national program with |
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| 77:10 | National Institute of drug abuse. But going to be better because now there's |
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| 77:16 | to be competition. So molded powder not going to pass, there's going |
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| 77:20 | be more varieties and people that are into this or not lose government |
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| 77:25 | but also in university entities, but entities, which means they will really |
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| 77:30 | the ways to commercialize these elements and formulations that they will produce from their |
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| 77:35 | growth that are federally approved and those separate from the state regulated growth. |
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| 77:40 | this year, state of Texas and fact, last year 2021 released the |
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| 77:45 | in texas that talks about institutional review and research of cannabis with medical schools |
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| 77:51 | hospitals from the dispensaries. And this is in conflict with federal rules. |
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| 77:57 | the state hasn't even released. So you have, about a year later |
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| 78:01 | have a rule how you can do on cannabis from the dispensers and you |
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| 78:06 | cannot do research Cannabis from dispensaries. probably won't be able to do it |
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| 78:11 | year. You probably won't be able do it until it's federally completely |
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| 78:15 | which means that the federal government Okay, it's not just these 11 |
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| 78:21 | with Mississippi, it's all of the . If they have agreements with medical |
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| 78:26 | and universities, these universities from these schools allow them to do the |
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| 78:33 | We federal government, we're not gonna anything about it. We're going to |
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| 78:36 | them to do that research. Because then very quickly we would be |
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| 78:42 | to tell what formulations of these What formulations of these anonymous help specific |
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| 78:49 | . Health anticancer activity help in glioblastoma pancreatic cancers. If they do but |
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| 78:55 | do not. We would have these just like the humanity was able to |
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| 79:01 | up with a vaccine for Covid within than a year. Okay we could |
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| 79:08 | that actually with many different diseases and this plant that offers so many fantastic |
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| 79:15 | properties and that it is being so used and outweighs. Like I said |
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| 79:21 | harms that it can cause a minimal state of texas also. And the |
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| 79:28 | state governments, they have a different from the D. A. And |
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| 79:34 | have this approved medical cannabis for a Alzheimer's autism, cancer, any |
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| 79:41 | CTE chronic traumatic encephalopathy, Parkinson, neuropathy, numbness in your toe, |
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| 79:48 | to nerves in your toe. You for texas compassionate use program. If |
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| 79:53 | have the diagnosis of that with qualified approved position. PTSD seizure disorder, |
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| 80:02 | . This program started in 2017 was seizure disorders. Now you have all |
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| 80:07 | these other conditions plus over 100 incurable disorders. If you have a diagnosis |
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| 80:14 | that, we can get to the , the department of public Safety for |
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| 80:18 | website to find out about these different . And we will actually know about |
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| 80:23 | disorders. Will study neurodegenerative disorders in in the next section coming up. |
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| 80:29 | this is what the state says. okay for all of these people to |
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| 80:33 | medical Canada's FDA says it's only okay use it for seizures and epilepsy, |
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| 80:42 | diet all the CBD and it's only to use it for vomiting and, |
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| 80:47 | uh, and uh, nausea. what FDA said. So the federal |
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| 80:56 | says you have access through our federal two medications to products to treat essentially |
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| 81:08 | conditions, thousands and seizures. That's the federal never moves. Mm |
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| 81:18 | The states say You have 10 Let me guess. 2000 different products |
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| 81:28 | any condition you'd like to the state texas would say Trades, you |
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| 81:35 | 115 plus conditions with, there's a there there is a legal fact, |
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| 81:46 | pharmaceutical system and why these drugs, drugs are approved drugs because they go |
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| 81:52 | safety and efficacy studies and a lot the medical cannabis products. People just |
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| 81:59 | it. And this is what I the system of reality. People experimenting |
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| 82:05 | testing different things on themselves, but using it. The truth lies somewhere |
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| 82:13 | between the two programs and I believe the two programs are going to start |
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| 82:19 | with each other closer and closer. , so with this, we're gonna |
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| 82:35 | talking about medical |
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