| 00:00 | This is Lecturer 13 neuroscience, and continue discussing neural transmission. The last |
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| 00:09 | of lectures we discussed that excited Terry glue dramaturgical synopsis upon the release of |
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| 00:16 | neurotransmitter and that transmitter binding to limit will cause influx of sodium on positive |
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| 00:25 | . Coming into the south will cause polarization the plasma membrane in the form |
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| 00:30 | excited terry and pasta potential post synaptic e p s p in the Gabba |
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| 00:38 | inhibitory central nervous system synopsis the gabba be released in Gabba will bind to |
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| 00:47 | receptors. In this case, we're about high on the Tropic Gabba a |
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| 00:52 | channels on the chloride influx will take Negative charge coming inside the cell will |
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| 00:58 | this hyper polarization recorded posson optical in form of inhibitory parts Synaptic potential I |
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| 01:06 | We distinguish between I on a tropic metal book. Tropic synaptic transmission I |
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| 01:12 | a tropic synaptic transmission is when you the binding of your transmitter. And |
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| 01:20 | same uh, receptor channel is a that conducts ions and medical tropic |
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| 01:28 | You have neurotransmitter binding the G protein receptor, which can the fact either |
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| 01:33 | protein, gated ion channels or enzymes , influencing the facts of secondary messengers |
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| 01:41 | the cells. So we have now way that channels can be gated by |
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| 01:47 | can channels can be gated by Liggins will open the channels and now |
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| 01:53 | also know about G protein gated ion . We discussed neurotransmitter systems and will |
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| 02:01 | this again, but acetylcholine synthesis of Colleen, degradation of acetylcholine, |
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| 02:08 | common necessaries And what role Alzheimers medications nerve gas is playing the synapse. |
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| 02:14 | all very important. Also, the that you have in the CNS two |
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| 02:18 | of the acetylcholine receptors I on a which is nicotine IQ acetylcholine receptor Meadowbrook |
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| 02:26 | which is glued in, which is protein coupled receptor. And so you |
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| 02:32 | signaling through both of these receptors and looking thio the you know, |
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| 02:38 | But these two receptors, one of is a receptor channel. Another one |
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| 02:42 | a g protein coupled receptor in the receptor. The natural agonist endogenous produced |
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| 02:50 | lee within our bodies. As a Colleen is producing our brains and our |
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| 02:55 | and settle. Colleen will buy into Yucatan Nick I on a tropic receptor |
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| 03:01 | most Karen IQ or a medical tropic receptor. Each one of these receptors |
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| 03:07 | have exogenous substances, so exogenous agonists the continent receptors, nicotine and exogenous |
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| 03:16 | form. Apparently, receptors must current . Ari is exogenous antagonists and atra |
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| 03:24 | exogenous. It's also antagonism. So you have is I am my |
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