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00:02 | This is lecture 22 of Neuroscience on endocannabinoid system and medical cannabinoids. And |
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00:12 | , this is me and it's not A I picture I'm standing in the |
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00:18 | of hemp plants in Europe and hemp uh cannabis plants. So besides being |
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00:28 | professor here, I I also have an interest in having more understanding on |
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00:37 | hemp, having more scientific research and on hemp and cannabis in general and |
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00:44 | this could be applied for various pharmacological conditions and applications in general. So |
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00:52 | have entrepreneurial side to myself and uh of the links I may have in |
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00:58 | folders is a TED talk I gave 2015 and that TED talk changes the |
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01:02 | trajectory the way I think not just as a scientist, but also as |
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01:06 | person who tries to understand the reality outside the lab on the reality of |
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01:13 | marketplace, the reality of business And so being actively involved since 2012 |
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01:21 | with the Bauer School of Business for few years and helping their executive M |
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01:26 | A s program. So I have vested interest in in just learning about |
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01:30 | myself and I learned a lot and have to tell you that even as |
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01:33 | scientist running the lab, you're sort like a business person because you're managing |
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01:38 | , you're managing the accounts, the , you're asking people for money, |
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01:42 | is you're writing grants. This is you have to think about. You |
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01:46 | the academic career is a professor. can be just a teacher if you |
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01:52 | to, you can be an academic just a teacher or you can do |
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01:56 | be a teacher and do research. when you do research, that means |
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02:00 | have to get money, that means have to count money and spend it |
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02:05 | . You have to hire people, people and so on and having some |
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02:09 | experience. Now in the business actually, I understand how inefficient a |
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02:17 | of academia is actually in handling and handling, especially the resources that are |
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02:23 | a lot of times. So one by grant pieces of equipment that uh |
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02:28 | around for 10 years being used a of times. So there's virtue in |
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02:34 | , there's virtue in business, there's in the world in general. |
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02:38 | the way we shape our understanding of is still really stigmatized. So if |
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02:43 | called everybody, we wanna talk about , we we gonna talk about |
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02:47 | medicinal marijuana, medicinal cannabis. People say, is this legal in |
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02:53 | Like to talk about it? Uh to use it. There's a |
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02:57 | program in Texas that we'll talk about general in the world. There has |
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03:03 | in opening and liberalization of how we and how we access and use cannabis |
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03:09 | medicinal purposes, but also for adult or recreational purposes. Historically, the |
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03:16 | why we have so much stigma on and marijuana is because of the Reefer |
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03:24 | campaign that was started in 1930. shortly after alcohol prohibition ended at some |
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03:31 | , this country prohibited the use of and you had all of these gangs |
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03:35 | boozers running alcohol from Canada across the , right? Al Capone, um |
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03:45 | and the whole subculture of illegal alcohol until it was legalized. Again, |
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03:50 | condition was lifted and shortly after cannabis criminalized and it was criminalized on no |
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03:57 | ground but political and special interest In other words, the medical community |
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04:03 | not asking the government to criminalize The medical community was using medicinal corporations |
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04:10 | cannabis, cannabis, tinctures, cannabis , cannabis ointments that contained cannabis uh |
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04:19 | pharmacies in the beginning of the 20th would contain a lot of these kind |
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04:23 | a botanical extracts and preparations. Granted lot of them were unsafe because there |
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04:28 | no standardized ways of preparing them. at the time, we really didn't |
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04:33 | what are the active ingredients in these botanicals and plants including cannabis. |
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04:39 | the government turned against cannabis and decided criminalize produce a lot of agents. |
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04:45 | had detrimental consequences to reefer madness, just on the stigma, but on |
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04:54 | criminal aspect, on the racial aspect criminalization of cannabis, of how it |
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05:00 | up putting mostly uh brown and black behind the bars because of these |
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05:07 | Although this didn't mean that those ethnicities those Racists used cannabis more so than |
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05:13 | white people did. So it was in that respect. It was supported |
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05:18 | special interest. This campaign anti cannabis very influential American companies that were helping |
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05:25 | the legislatures at the national level that involved in chemical injustice, petroleum industries |
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05:33 | lumber industries because Hamp could have replaced of the paper that was made and |
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05:39 | is made from trees. And if have a lot of interest in lumber |
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05:45 | in making paper from trees and the factories built for that, well, |
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05:50 | you may want to go against another industry such as Ham or cannabis, |
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05:56 | the reality of things the way this works. So reefer madness comes out |
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06:01 | these statements that if you smoke cannabis use marijuana, women cry for |
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06:08 | So you get addicted, men die it. So they get aggressive and |
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06:12 | each other and kill each other. It's for adults only this movie of |
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06:17 | Madness. Uh Burning question dope created avalanche into frightful perversions, makes beasts |
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06:27 | men and women. Uh There are racial aspects here where if a white |
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06:37 | is gonna smoke marijuana, she is have an interracial uh relationship. And |
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06:42 | also negative. So we're talking about thirties. Now, the repercussions of |
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06:47 | campaign has persisted for almost 100 And what happened in the United States |
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06:53 | this campaign has followed a lot in countries and at the level of the |
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06:58 | Nations and international laws without really clear for why this is such a dangerous |
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07:06 | frightful substance, why it should be as such. And that stigma from |
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07:13 | thirties created campaign started being uh alleviated the seventies when the flower Children came |
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07:21 | in this tree huggers. Uh and were going to all of these rock |
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07:26 | and uh using cannabis and it started up and that's where decriminalization of cannabis |
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07:34 | was in 19 seventies on the west in Oregon. So cannabis and marijuana |
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07:42 | still placed on schedule one by the government and schedule one means that this |
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07:50 | a substance or, or drug that dangerous, that is addictive and has |
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07:56 | medicinal values or applications officially. So we know, laws are always behind |
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08:01 | the federal level, on the state , you're like, wait a |
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08:05 | there's medical cannabis, you told us the state of Texas and in and |
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08:08 | Colorado and everywhere around this country for most part. So how is that |
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08:14 | from the state? Laws from state are different from federal laws while they |
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08:18 | , we all know. Again, is the reality we live in is |
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08:22 | federal law for abortions or a lack . And there are state regulations and |
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08:28 | for abortions as well. I'll do two co exist. This is the |
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08:32 | States of America. The matters are and the federal government is typically lagging |
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08:38 | of anything that is emergent or And the states like on the west |
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08:43 | are typically the ones leading the then they're joined by north east coast |
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08:48 | the Middle America fills in eventually. the laws change as the case is |
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08:53 | Canada, for example, that is now. So now we criminalize cannabis |
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09:00 | the thirties, but we really don't what we criminalize. We just know |
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09:03 | when people smoke marijuana, they get and when they get high, they |
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09:08 | a different effect from that uh cannabis or if they ingest a tincture, |
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09:15 | get high, but then they get and then they go to work and |
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09:18 | they get high and it's a and a drug that doesn't kill people, |
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09:22 | we don't understand what's in it until is this technique that's invented high performance |
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09:29 | chromatography or H P L C, analytical chemistry technique used to separate, |
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09:34 | and quantify each component in the So the way it works is that |
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09:40 | example, if you are and the times were preparing any tinctures and you |
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09:47 | so dissolve something, you dissolve some substance, you put some leaves and |
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09:52 | alcohol and you swish it around and you wanna know what have you extracted |
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09:57 | those leaves. So you would put component, whatever you extract it. |
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10:06 | if you pass it through these OK. It's liquid solvent containing the |
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10:13 | through a column, fill with a absorbent material. And from this |
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10:19 | it goes into this H P O column and each component in the sample |
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10:24 | slightly differently with absorbent material in this , causing different flow rates for the |
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10:31 | components or active ingredients, chemicals in mixture and leading to the separation of |
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10:39 | active ingredients as they flow out of column. And then we have a |
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10:44 | in the sixties and and and Uh it would be like a little |
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10:49 | that would print this. Now it in digital on the computer and what |
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10:54 | tells you is that each one of peaks is a certain substance, a |
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10:59 | chemical, certain active ingredient and it you also the amount a percentage of |
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11:07 | active ingredient within then whatever mixture you're . So a lot of analytical chemistry |
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11:17 | that study botanical preparations, safety metal contaminations, pesticides, herbicides will |
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11:24 | using this type of techniques. There's mass spectroscopy that would be added on |
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11:29 | , for example. But this technique botanicals will produce and you will hear |
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11:35 | word for products that are especially for , cannabinoid products, CVD products, |
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11:42 | products and some other botanicals like If you are buying some turmeric extract |
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11:49 | something, it may have what is the C A, which is a |
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11:53 | of authenticity or a certificate of which says that a certified analytical lab |
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12:01 | tested this preparation and has found certain of chemicals in it at certain concentrations |
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12:07 | hopefully found no contaminants, no metals such. So the point being is |
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12:14 | we have this technique and this technique 1964 is being used by Rafael |
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12:20 | Doctor Rafael Maul passed this year about month and a half ago. In |
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12:25 | nineties, Rafael Masullo uses uh uh chromatography and isolates him correctly describes the |
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12:34 | of delta nine T H C or nine tetra hydro Komal. OK. |
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12:43 | nine T eight C. And it's , there's a wonderful movie online about |
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12:48 | discoverer about Rafael Shula that he discovers H C. And of course, |
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12:54 | any good scientist before he tries to any experiments on animals or on |
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13:01 | He takes some of that T H home and invites guests and his wife |
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13:06 | uh bakes a chocolate cake and there eight slices and each slice has 10 |
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13:13 | of Dolphin line THC. There's eight , eight guests and this is in |
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13:20 | and they have this chocolate cake. this is 19 sixties nobody really knows |
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13:24 | is an active substance, one we're not talking about cannabis, |
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13:29 | So he sees a different the fact a couple of people are laughing their |
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13:34 | off. A couple of people are and talking and then somebody's having a |
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13:40 | attack and anxiety attack and they're withdrawn the group. And to this |
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13:44 | we know that Delta Nine T H has a different effect in different people |
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13:49 | has a negative effect on a portion people. It also has negative consequences |
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13:54 | use of cannabis or Delta Nine T C as well. So now Rago |
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14:01 | does that, he also does some with monkeys, does some experiments with |
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14:06 | and then a lot of the research is beneficial that shows beneficial effects of |
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14:12 | H C or any cannabinoids or cannas marijuana becomes systemically suppressed and you cannot |
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14:19 | funding for it. And this is fact too, this is just the |
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14:24 | . So if in the eighties, wanted to apply for a grant and |
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14:27 | saw a positive effect from cannabinoids, agencies would ask you to articulate. |
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14:32 | you prove that it has a negative instead and then you are more likely |
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14:37 | get funding. So there's this bias is, you know, going through |
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14:42 | through the government and goes into the agencies and affects all of the academia |
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14:48 | all of the research. And to date, we can get schedule one |
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14:54 | . Water on Sigma Out Bridge is catalogs that will get shipped in and |
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14:59 | put it on the shelf and we 50 different vendors trying to sell different |
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15:04 | one substances that are synthetic including Delta IC. But to this date to |
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15:11 | in a cannabis plant, a marijuana to study in the lab to do |
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15:16 | in humans. Despite the fact that is vastly prevalent through these different programs |
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15:21 | date, it's still very, very , very, very restrictive. So |
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15:27 | had very limited access to federally approved that are allowed to provide this cannabis |
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15:35 | for research plant. Now for synthetic H. So you go out and |
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15:39 | any catalog off the shelf with any chemical company and and they will be |
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15:44 | them. So again, this still , the stigma coming out is |
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15:50 | we're still not done with 100 It's going to be another 10, |
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15:53 | years before all of this kind of more implemented into, into reality. |
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16:00 | since there's a discovery of natural T C and that T H C is |
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16:04 | from cannabis extract, he actually takes from the police station and isolates T |
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16:11 | C from hashish because people are using and it's not a different drug. |
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16:15 | just a concentrated form of marijuana, concentrated form of cannabis and he isolates |
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16:21 | C from that. So now we that in the plant in that concentrate |
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16:25 | the plant is in ingredient Delta Since then, there's pharmaceutical preparations to |
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16:31 | synthetic Delta nine T H C navi . Typically 2.5 mg T H C |
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16:39 | you ingest for IZED stimulation, it's anti and also anti wasting and |
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16:48 | and radiation therapy. Typically in advanced of cancer and terminal illnesses. And |
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16:55 | is really interesting that this came out the eighties because the hippies discovered this |
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17:00 | the sixties, late sixties and seventies California and Oregon. And they discover |
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17:06 | because there is an uh there's AIDS going on, there's HIV. And |
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17:15 | don't know how to deal with that and AIDS is deadly and this is |
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17:20 | auto, uh it's an immune deficiency disorder. Uh eventually it's so difficult |
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17:29 | person that has advantages of AIDS, go through what is called wasting |
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17:35 | They, they are nauseous, they wanna eat and they're losing a lot |
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17:39 | weight. And what people saw on west coast in Oregon and California is |
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17:45 | they give some of these cannabis, tinctures and concentrates and even inhalation products |
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17:53 | these patients is that their appetite would , they would eat a little bit |
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17:58 | therefore they would live a little bit . Uh-huh. So, you |
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18:03 | of course, the pharmaceutical agencies and that had money saw that capitalized on |
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18:10 | and patented a medication from THC, THC. And that's how typical it |
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18:17 | , right. Somebody's grandmother, grandmother some concoction with mint and lemons and |
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18:22 | else. And it's been around for years and then some scientist picks up |
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18:27 | , you know, has some pain says it help me from pain. |
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18:29 | I'm gonna take it to the I'm gonna research it, find some |
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18:33 | . Usually most of the pharmaceutical drugs we had 80 85% of all of |
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18:38 | formulations that derived from botanicals and then size uh in the lab from |
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18:45 | So they're not plant derived, but don't have planned derived cannabis derived medications |
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18:51 | 2005, which is Delta nine T C and CD D. It's a |
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18:56 | to 12.7% T H C 2.5% The vix, it's produced in UK |
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19:04 | a British company and it is still available in the United States. It's |
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19:10 | in over 25 different countries, especially Europe. And it's a buckle |
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19:16 | Buckle spray is a cheek spray. why would you want to spray medicine |
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19:23 | the cheek? Because if you take tablet and you swallow something, it |
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19:29 | falls into P H 3.5 and the juices and start getting digestive. So |
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19:37 | a fraction of it goes into the system and then it gets absorbed through |
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19:43 | digestive system into the blood. And way of effectively getting active ingredients through |
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19:50 | consumption is through the cheek, the of the cheek, sublingual under the |
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19:56 | and upper seal esophagus regions. This where you have the highest abor absorption |
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20:02 | many of the active ingredients. So , pills that you swallow actually not |
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20:08 | effective as some of the oral preparations will prolong the time of that active |
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20:15 | in the mouth or would expose directly lining of the cheek to a spray |
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20:21 | basically, you know, breaks it into smaller molecules in the air. |
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20:26 | use this anti spastic and anti anti spastic spasms and multiple sclerosis. |
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20:33 | we talked about multiple sclerosis. It's autoimmune disorder, demyelination. One of |
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20:39 | mutations and chromosomes and bone. We about chromosome 18, right. You |
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20:45 | to have two bad. All it diagnosed typically in the thirties, symptomologies |
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20:51 | if you'll have tremors, you will spasms and you will have pain is |
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20:55 | have C N S demyelination. you can put it together with what |
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21:00 | example, Rama Chadron talked about how have Sonatas, senses system plasticity. |
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21:06 | you have demyelination of the of the parts of the neurons and motor complexes |
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21:12 | basal ganglia, different areas of the . And that will result in poor |
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21:18 | . Let's say if it's in the system, motor cortex, a matter |
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21:21 | sensory, poor gait, poor poor motor coordination, abnormal signals from |
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21:28 | motor cortex may cause lock up and of the muscles and spasms can be |
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21:34 | and they don't always have to be in the arms or limbs. They |
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21:38 | also be in the diaphragm, which be deadly because you need diaphragm to |
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21:43 | and relax in order for you to . So, it's an anti spastic |
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21:48 | anti pain and multiple sclerosis and a medication that was produced by the same |
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21:54 | companies that 10% can have a dial CV D and CBD is the second |
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22:00 | prevalent phyto cannabinoid. So, these synthetic cannabinoids, both of delta C |
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22:07 | these are phyto cannabinoids, which means they are extracted or derived from the |
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22:13 | plant that um for the um is the pathway that you learned last unit |
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22:23 | it um does uh a negative feedback this side as well? We're in |
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22:34 | . It's a very good question. you know that most of the drugs |
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22:37 | the pharmaceutical level? They don't even exact mechanisms of action for drug to |
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22:43 | on the market? You don't really to know the exact mechanism of action |
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22:46 | because there are disorders, for like depression, what you need to |
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22:51 | is that the drug is safe and and you do that through a number |
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22:56 | clinical trials. So you start with research and your typical in rodents and |
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23:02 | you do clinical trials. And if show in humans that certain combination like |
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23:07 | to 1 T H C to CV anti spasms. You don't really have |
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23:11 | show the mechanisms by which it alleviates spasms. And there are some, |
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23:16 | you will see some short term mechanisms phyto cannabis can act like endo |
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23:21 | So they can regulate neurotransmitter release. can regulate potentially over excitation and too |
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23:28 | of the glutamate release. Maybe that's you're going. But it can also |
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23:31 | slower processes such as inflammation and inflammation also contributing to abnormal neuronal activity and |
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23:40 | and potential lockup of these muscles and . And of course, if you |
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23:44 | something bucky, it's systemic. You , of course, MS is the |
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23:50 | nervous system disease, but the consequences be still systematic throughout the whole |
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23:56 | And here is a substance that is systematical. It will have an effect |
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24:01 | the brain through this buckle absorption into bloodstream into the brain, but also |
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24:06 | the whole body too. Now, 10% CD D is an oral solution |
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24:14 | , tincture, that's anti convulsive or seizure medications for Dr syndrome and Len |
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24:21 | . So if you recall, we this concept of medical cannabis when we |
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24:28 | about Dr syndrome. Last lecture, a mutation C N one A gene |
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24:34 | mutates voltage gated sodium channel that causes I severe my chronic epilepsy of |
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24:41 | which is also a syndrome. So is the medication for drive A syndrome |
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24:48 | Leonard gestal epilepsies, which are also form of very severe childhood epilepsy. |
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24:56 | , and that's all folks. So uh 64 it's gonna be 60 years |
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25:02 | 2024 uh millions of people have used and cannabinoids around the world. Hundreds |
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25:12 | millions, there's states, 37 or states that have medical cannabis programs in |
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25:20 | , they're alone. It's a very program, but it's over 50,000 patients |
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25:24 | Texas alone. But from pharmaceutical you basically have two choices T H |
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25:34 | synthetic in this country, synthetic PC CBD. So for, you |
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25:41 | chemotherapy treatments, terminal illness or for intractable severe forms of and that's |
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25:51 | So we'll see what the next uh years, 30 years brings because in |
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25:57 | development, we quite often see what called the first generation, second |
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26:01 | third generation drugs. And there's a of breakthroughs that happen. And I |
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26:05 | believe this is an unprecedented opportunity for community to start understanding what the dispensaries |
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26:13 | the cannabis companies are preaching that you to take this 1 to 13 to |
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26:18 | , 15 to 7 and you're gonna , it's gonna help you from pain |
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26:22 | you're gonna do this. There's no for these specific formulations, there's a |
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26:27 | of evidence of positive effects, but is also evidence of negative effects. |
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26:33 | that's why doctors would still recommend pharmaceutical because they safe in applications as far |
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26:38 | the negative effects of cannabinoids and cannabis talk about it in a second, |
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26:45 | the reason why we have such I don't know, affinity or strong |
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26:54 | also from cannabis or cannabinoids into our . Then through the ages and cannabis |
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27:02 | because we have other phenomenal system. talked about CV, one receptors and |
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27:06 | two receptors in the brain. But a much larger system that is a |
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27:11 | system is one of the major body brain homeostatic and regulatory systems and uh |
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27:21 | , major components. There are two leuco, there are other leos, |
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27:27 | the two major ones are an anam two A G and two major cannabinoid |
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27:35 | . So CD one and CD And apart from being expressed in the |
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27:40 | , C B one and C B receptors will be expressed throughout the |
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27:45 | C B, one receptors in the are dominant in neurons and C B |
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27:50 | receptors are dominant on glial cells in microglial cells. Now, this is |
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27:57 | endocannabinoid and this is the phyto cannabinoid nine T H D. So you |
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28:02 | see that there's structural resemblance and just endo cannabinoids interact with the CD one |
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28:09 | CD two receptors, phyto cannabinoids. there's a variety of phyto cannabinoids. |
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28:14 | C DH C A CD D CD A CD G, CD D |
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28:18 | CDC CD G. There's a whole of phyto cannabinoids. Most of them |
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28:25 | we know are called major phyto DH C CD D and CD |
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28:30 | But then there are minor phyto That means that they're not as abundant |
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28:35 | nature or rare PTOs. Uh There's whole uh slew of them and we |
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28:43 | don't understand uh a lot about a of their functions or interactions or different |
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28:49 | of how it interacts to cause any effect. However, I look a |
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28:55 | gets activated, really earned early on a newborn has to start suckling uh |
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29:08 | milk, mother's human milk increases the of endo cannabinoids. In particular in |
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29:16 | , think about it if T H or smoking cannabis or consuming T H |
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29:22 | makes people hungry, that's what was from wasting syndrome, right? I |
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29:27 | it will increase appetite and let people a little bit anti nausea. So |
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29:34 | and amide acting, the CD one is not only controlling CD two |
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29:38 | not only controlling that neural transmission, it also is encouraging promoting hunger so |
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29:46 | the so that the person could so the person could eat basically and continue |
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29:53 | . It gets activated with pain and . So it's a modulatory system for |
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29:59 | and stress. So endo cannabinoid production newborns with suckling with pain and stress |
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30:07 | immune function. CD. Two receptors predominantly expressed in the parts of the |
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30:14 | , bone marrow spleen that are going a massive immune response and uh sorry |
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30:27 | you have a response to to Of course, memory, it can |
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30:35 | memory and it will actually help us things. So, and the cannabinoids |
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30:41 | forgetting things endogenously is an important mechanism survival. Because if you lose somebody |
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30:52 | you love so much, you are this overwhelming state of grief. But |
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30:59 | a few months later, a few later, people are no longer in |
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31:04 | state. And part of that is forget things because if we didn't forget |
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31:09 | , especially negative or bad things, distressing things, we could possibly not |
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31:16 | about our life in a normal So it's a normal protective mechanism. |
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31:22 | so and the cannabinoids will be kind a regulating in a way the forgetfulness |
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31:28 | the forgetting in memory. But it's important in the plasticity and encoding uh |
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31:35 | , of the information. Uh it's activated with inflammation. So CD two |
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31:43 | and marco glia release cytokines, they the immune and inflammatory response in the |
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31:50 | . It's also involved in thermal regulation has other effects. So these are |
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31:56 | cannabinoids and because phyto cannabinoids will interact the same system, end the cannabinoid |
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32:03 | , they also have similar effects of , stress modulation, appetite, memory |
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32:11 | , inflammation, and so on. how you consume medicines. I've talked |
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32:20 | this from the very beginning because I that some of you are going to |
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32:24 | on and develop really smart pharmaceutical neuroprotective preparations, anti neurodegenerative drugs because |
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32:33 | taking my my course and you love . So some of you will pursue |
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32:39 | to always tell you to think about . You know, you ingest anything |
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32:43 | talk about. If you ingest anything is the effect immediately you have a |
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32:50 | or you have pain in some joint something and you take a couple of |
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32:54 | , you know, it's not like seconds later, the pain is going |
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32:58 | . You know, the doctors will you wait 15, 20 minutes, |
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33:05 | ? And so if you ingest cannabinoids any cannabinoid preparation, the reason why |
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33:11 | talk about that is because you will about these things called the gummies. |
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33:17 | heard about the gummies, right? is in the gummies. Now, |
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33:21 | and beetroot is in the gummies and is sold in the gummies too, |
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33:27 | medicinal way of delivering substances. Uh nonetheless, it's oral and Josh. |
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33:35 | it's better if you instead of chewing swallowing because this is what you do |
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33:39 | gummies. It's similar to the the tablet you put in your mouth |
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33:43 | table. What you swallow with gummies 12345 chew and you swallow it with |
|
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33:52 | . They get distributed throughout your buckle sublingual areas. So it's a better |
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33:58 | of delivering. But unfortunately, there that many of these format products in |
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34:05 | either pharmaceutical world or in medical cannabis . Another uh way that is very |
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34:13 | is topical aluminum. So creams there are CV one and CD two |
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34:21 | on the nerve endings. That we . Remember the soma of sensory motor |
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34:26 | endings that are there, there are , one CD, two receptors in |
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34:30 | nerve endings. So it has to a transdermal preparation has to cross the |
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34:37 | . And if you're making a product a cream and it doesn't cross to |
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34:41 | these canna receptor swab, we're not what effect it's having. But there |
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34:46 | a lot of topical preparations uh out from cannabinoids, but there's also no |
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34:52 | preparations on the CV S shelves that 10% menthol with count four. You |
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34:57 | , if you have an injury in knee, rub it on, you |
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34:59 | , it keeps it cool, keeps warm, it helps, it really |
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35:02 | . You know. So there are things there, but we don't understand |
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35:06 | on the side of the cannabinoids, we do know that it will control |
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35:11 | and can control pain too. Now, if you have oral ingestion |
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35:19 | lot of times with cannabinoids and with pharmaceutical medication, people will say start |
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35:25 | , go slow, which means take . Advils don't take 16 and wait |
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35:30 | 15, 20 minutes. If the is still excruciating, maybe take a |
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35:34 | more, but then lay off for hours. You come on because it's |
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35:38 | affect your metabolism. It's gonna affect bla now you're taking something potentially like |
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35:43 | that is DH C that causes a effect. So you have to start |
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35:48 | , go, slow, start, , go slow. It has a |
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35:51 | fact, it depends on your Some things, you know, most |
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35:55 | the time the Ibuprofen preparations are standardized you're taking a anti analgesic, you |
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|
36:02 | , and you'll feel in the fact 10, 15 minutes, a lot |
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36:04 | the products that are on the medical cannabis market, vitamin gummy |
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|
36:10 | we don't know that there's no standardized of prepa preparing these different gummies. |
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36:15 | some of them may have an effect , 20 minutes later, some of |
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36:19 | half an hour later and some people hours later. And the fact once |
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36:24 | is through consumption is for cannabinoids is 6 to 8 hours. It's a |
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|
36:30 | effect. And most of the poisonings most of the da danger from these |
|
|
36:36 | uh ingestible cannabis products comes from when land at Denver airport and where is |
|
|
36:42 | dispenser? It's a very popular Google in Denver, where's the nearest dispensers |
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|
36:46 | the airport? And they go through and they get their gummies and they |
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|
36:50 | back in the Uber, you to go to the conference or to |
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36:53 | to the hotel or something like that they, you know, take a |
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36:58 | and then, you know, they in the car and Uber and |
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37:02 | you know, so it's another half hour and 15, 20 minutes, |
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|
37:06 | know, they ask their friend, you feel anything? No, I |
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37:08 | do anything. Do you feel No, I don't do anything. |
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37:10 | take another one. So, and where issues begin because then they take |
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37:15 | one. But then at the same the first one starts acting and it |
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|
37:20 | oxidized T H C gets oxidized in liver. Delta nine into the 11 |
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|
37:24 | , 11 0 H T C which has a intoxicating or high causing |
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37:30 | So now we getting a double whammy the first gun is starting to act |
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37:35 | an hour into it. And you're get another wave of that second one |
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37:40 | was swallowed maybe 15 or 20 minutes , it could be an additive effect |
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37:44 | it causes problems. Now, this also the most common way that Children |
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37:49 | poisoned because the products are prepared to like rice crispies and you know, |
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37:54 | gummies and such and when adults use and leave them unattended and pro in |
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38:01 | storage gives good hold of these gummies set the, you eat them. |
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38:05 | get poisoned. You can overdose from from cannabinoid. They go into |
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38:10 | into the hospital, they get their washed out, you could pass out |
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38:14 | a night and they go to school following day. But it's a traumatic |
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38:19 | , you know, especially if they very young Children to go through all |
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38:23 | this. So the whole marketplace and have to be a lot more responsible |
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38:29 | things that you know, look and like they're made for Children, but |
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38:32 | really more adult, you know, or intoxicating uses like alcohol. You |
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38:38 | be leaving, you know, little bottles that look like Squire juices |
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38:44 | kids, you know, uh to take on the way to school |
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38:47 | their lunch boxes. That's just, know, the way it is so |
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38:52 | to be responsible. The market has be responsible. Now is that the |
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38:57 | way to get the canal in the populous is done is the second most |
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39:01 | still is in the use of cannabis marijuana is in relation to smoking and |
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39:06 | vaporization. The difference between smoking and is in smoking, the the matter |
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39:12 | being burned. So it's typically 400 and above to 1000 centigrade and vaporization |
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39:19 | are built so that the heat, temperature below 400 centigrade, they heated |
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39:25 | about 303 150 C. And that's a lot of active substances from |
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39:31 | cannabinoids and also turbines will evaporate without combustion without burning the matter. So |
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39:38 | really a safer way is vaporization. the millennial generation is the first one |
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39:45 | is using more the vaporized products and rather than the smokable or uh combustible |
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39:52 | preparations from, from, from cannabis from tobacco as well. So |
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39:59 | it's, it's, it's also uh modern way of thinking that uh there's |
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40:04 | lot of harm from combusting and And uh we really need to know |
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40:11 | the benefits and the harm from the ingredients that we can either extract or |
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40:16 | without burning. Suppository uh is another way of getting cannabinoids into the |
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40:23 | Why is inhalation or suppository grade? when you inhale something, it goes |
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40:29 | your lungs, it goes into your vessels, it goes into your |
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40:34 | it's not going into your stomach, not going into your digestive system and |
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40:37 | going into the blood. Ok. suppository AOL or vaginal suppository is the |
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40:44 | way. There's a huge blood uh supply in those areas, huge sensitivity |
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40:50 | delivers it directly into the blood And so it bypasses the liver metabolism |
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40:56 | you would have through the digestive So you have to think about, |
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41:02 | know, how different preparations are used this, just not just with cannabinoids |
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41:08 | any pharmaceutical preparations. And that's something you should think about also. And |
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41:14 | as you pursue anything in the health field, let's talk about some basics |
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41:20 | cannabis. I call this cannabis and is one oh one. We have |
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41:25 | legal hemp. So United States federal allows for the growth production, processing |
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41:32 | sale of what we call hemp or hemp, which are typically these tall |
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41:38 | , although they don't have to be they, they by way, 0.3% |
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41:43 | H C in this country or So T H C is still viewed |
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41:47 | it's an intoxicating canna. We understand industrial purposes, we don't want any |
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41:53 | substances in there. We're gonna keep and most of Europe is a 0.2% |
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41:58 | H C Italy decided it is going be 0.6% T H C in |
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42:04 | Switzerland says it's gonna be 1% Czech said it's gonna be 1%. So |
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42:10 | does that mean? Is a real separation between industrial harm? He plants |
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42:18 | medical marijuana. There isn't, there's regulatory separation. The regulators in the |
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42:25 | States said that it's 0.3 regulators in said it's 0.6, it's country by |
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42:33 | and that's why it makes things even complicated because there's international trade, there's |
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42:38 | trade to it in this country as . So it's a complicated matter. |
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42:41 | typically these plants have grown for many purposes, really all and skinny I |
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42:47 | H C calendars can contain up to 36% T H C by weight in |
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42:53 | flour uh and typically grown smaller or least bushier and shorter to increase the |
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43:02 | of the production of what are called here for the cannabis flowers and they're |
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43:08 | concentrated, you know, female flowers ham. It's typically mixture, female |
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43:14 | male flowers. Because for him, will grow for seeds because seeds will |
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43:19 | a lot of really good oil and oil and a lot of protein in |
|
|
43:23 | . Ok. So, and you do that with this because you don't |
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43:26 | it, you typically drug meats or products and you're trying to drive the |
|
|
43:32 | H C level for intoxicating or medicinal because active ingredients can do both just |
|
|
43:38 | antiepileptic drugs that can make a person stop the seizure through activation. It |
|
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43:45 | make them intoxicated, feeling like So the same is with, with |
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43:50 | preparations, the high concentration, if a psychotropic molecule, intoxicating molecule, |
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43:57 | higher intoxicating effect but potentially a a medicinal effect also and also a higher |
|
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44:04 | effect potential as well. This is natural cannabis and can, this is |
|
|
44:12 | . This is going out of fashion little bit because these other things, |
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|
44:15 | delta eight T H C and delta T H C came into the market |
|
|
44:21 | well as hexahydrate, Cannavino H H and they're semisynthetic cannabinoids. But just |
|
|
44:28 | few years ago, this is fake chemicals that are produced synthesize that are |
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44:34 | synthetic cannabinoids. And the difference is the binding properties. So natural cannabinoids |
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44:40 | they bind to CV one receptor. CV, one receptors will regulate calcium |
|
|
44:47 | , presynaptic through metabotropic signaling. So binds to CV one receptor and |
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44:52 | it's called a partial agonist, binds and then it it dissociates from |
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44:58 | receptor. This is a natural You know, when you synthesize something |
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45:03 | synthetic, it can be a full , which means it binds to that |
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45:09 | won't leave it alone for two So when we're talking about these effects |
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45:14 | for 6 to 8 hours through ingestion inhalation is typically 33 to 4 hours |
|
|
45:20 | cannabinoids, phyto cannabinoids. Then you're about cool agonist that may have an |
|
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45:25 | for two weeks for three weeks. means it's gonna change potentially permanently brain |
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45:31 | and even the wiring of some of neuronal networks and could cause chronic mental |
|
|
45:37 | , especially with synthetic annoy. So is danger from consuming mostly high levels |
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45:43 | T H C. And it is recommended for people that have psychological problems |
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45:49 | have psychosis that are psychosis prone. it is, you know, adult |
|
|
45:57 | or recreational is available in many different States and countries around the world, |
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46:02 | few countries around the world. So can tell adults what to do. |
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46:06 | for medicinal purposes, you want to a medical supervision and you want to |
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46:12 | sure that you're consuming the molecules that been analyzed through H P L |
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|
46:17 | So you understand what are the active ? What are their concentrations that your |
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|
46:21 | understands that that is being used for purposes and even for recreational purposes because |
|
|
46:26 | consumers are becoming way more aware of active ingredients, right? Way more |
|
|
46:33 | of natural vegan. Uh No, GMO. Your generation, you guys |
|
|
46:41 | for different symbols of products whether it's products or food products that, |
|
|
46:47 | for, for a lot of it has to check off some |
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46:50 | No GMO vegan. I'll take you know, or others, you |
|
|
46:54 | , organic, it's fine. I'll that, you know. So now |
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|
47:00 | synthetic substances are typically applied on the matter. They're dangerous. They can |
|
|
47:06 | pros psychotic, they can induce schizophrenia by a single or two time |
|
|
47:12 | So, a lot of synthetic stuff just horrible. We can regulate natural |
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|
47:19 | that stinks and everybody knows what it . Our lives would be really better |
|
|
47:25 | there's a lot of synthetic stuff right . It's fentaNYL. Minute amounts, |
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|
47:32 | mg, no smell, some something somewhere you're dead one time |
|
|
47:40 | Ok. So this is, this really dangerous stuff when people start |
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|
47:45 | when humans start synthesizing, when humans that there's an effect that we can |
|
|
47:50 | somebody even more addicted to this version fentaNYL. Now, that's pure evil |
|
|
47:57 | the, the reason why people don't from people buy a lot of |
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|
48:02 | The people, why, why people die from cannabis or economics is the |
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|
48:09 | mic range of any system. And is my best explanation is that for |
|
|
48:16 | , if you're taking opioids, let's even talk about fentaNYL, which is |
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|
48:19 | very small dose is lethal for I believe it's two mg of |
|
|
48:24 | Well, let's talk about regular opioids the regular opioids have an effective |
|
|
48:33 | What is an effective dose? And do you use opioids from pain? |
|
|
48:38 | . It's typically from pain or analgesia effective dose is, is small. |
|
|
48:46 | means effective dose is, is gonna the pain or alleviate the pain at |
|
|
48:51 | partially or to the extent that it . Now, if you triple or |
|
|
48:57 | that small dose in opiates, it's lethal dose. So when a patient |
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|
49:05 | taking something from pain or they have opioid pump that they can access to |
|
|
49:10 | they can inject themselves more opiate then if they triple or quadruple this |
|
|
49:17 | , the effective dose that dose is and that's because uh in the brain |
|
|
49:26 | receptors are found in the brain stem the areas that are controlling vital bodily |
|
|
49:33 | , the heart rate and the So we've increased just a few times |
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|
49:41 | the effective dose. Opioids are lethal a lot of synthetics and fentaNYL is |
|
|
49:47 | same way they're lethal. So why it with, with cannabis? Cannabis |
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|
49:54 | dose? Well, many different it's different dose. But let's say |
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|
50:02 | a joint is an effective dose for to either have a medicinal effect, |
|
|
50:08 | marijuana cigarette joint, whatever or has high causing effect. Sometimes it causes |
|
|
50:16 | people to get high, sometimes it's parcel. But let's say one is |
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|
50:20 | effective dose for either medicinal effect or the high effect to put cannabis to |
|
|
50:27 | a lethal dose, you have to about 1000 joints in about 15 to |
|
|
50:32 | minutes and not even snoop doggy dog do. So. The point is |
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|
50:38 | this system has a very wide dynamic of the lethal dose is very hard |
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|
50:45 | achieve. I think if you tried hard with concentrates that are concentrated preparations |
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|
50:51 | T H C and if you, know, had high heat and were |
|
|
50:56 | , there would be other problems from , from consuming heat from other |
|
|
51:02 | But the fact of the matter, system and the cannabinoid system, cannabinoid |
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|
51:07 | activation has a very wide dynamic You can, you can use an |
|
|
51:12 | of the rubber band. You know happens when the rubber man gets |
|
|
51:18 | you stretch it a little bit and breaks right. So that's sort of |
|
|
51:22 | like it doesn't have much of a range. So that's the opioid |
|
|
51:26 | it has an effective range, you it a little bit, it |
|
|
51:29 | you die. All right. With cannabinoids and cannabinoid phyto cannabinoid activation, |
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|
51:36 | have a very broad dynamic rate. you can stretch that rubber band, |
|
|
51:41 | comes back three or four hours later it can be stretched again. There's |
|
|
51:46 | . So for medicinal purposes, people have a small dose of cannabis. |
|
|
51:51 | may need a higher dose. there is a tolerance increase in use |
|
|
51:56 | cannabis. But in, in general substances, they are either full |
|
|
52:02 | they're dirty, they're dangerous combined to cannabinoid receptors in white and end the |
|
|
52:09 | system. The cannabinoid activation has a dynamic range. Therefore, it's non |
|
|
52:14 | but surely you can overdose from cannabis T H C. Uh cannabis parts |
|
|
52:21 | bio active molecules. There are different to cannabis plant. I really like |
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|
52:26 | plant because the stems uh can be for production of cellulose. It also |
|
|
52:36 | a conductor, very highly conductive uh materials that are even more conductive than |
|
|
52:43 | than graphene. Actually, uh the will not have any cannabinoids, but |
|
|
52:50 | very rich in essential fatty acids. 35% whether these omega three or omega |
|
|
52:59 | . This is what your doctor tells . You have to take olive |
|
|
53:02 | you have to take the Omega So, hemp seed oil that's prepared |
|
|
53:07 | hemp seeds and you buy it anywhere the grocery store. And Amazon has |
|
|
53:11 | of the best ratios of omega three omega six. I can't remember now |
|
|
53:15 | direction, but I just know that's good ratio. I give it to |
|
|
53:19 | dog and I put it on my hemp seed oil and my dog loves |
|
|
53:23 | when I put it in, in her food, um, seed |
|
|
53:28 | has this other substance called camp and and in general there's a whole culture |
|
|
53:35 | sprouts and microgreens, right? You to the grocery store, you can |
|
|
53:40 | a big bag of potatoes for three . Or you can buy a really |
|
|
53:45 | container of microgreens for eight bucks. this was going to be like small |
|
|
53:50 | greens, the bean sprouts, alfalfa like all of these things. And |
|
|
53:55 | reason why is because they're small, typically they have very high levels of |
|
|
54:00 | molecules, very high levels of Ok. So they're babies, but |
|
|
54:05 | are like super rich in nutrients and And this is anti inflammatory that come |
|
|
54:11 | sprout. So don't be surprised uh the west coast, it already |
|
|
54:15 | but don't be surprised that will be , microgreens in the grocery store near |
|
|
54:19 | pretty soon. And uh cannabinoids that talking about T H C CD D |
|
|
54:26 | G, they are produced in cannabis and they're produced in these granular |
|
|
54:35 | And also that's where the smell of comes from because there's a lot of |
|
|
54:40 | that are produced in these glandular So this is what they look |
|
|
54:47 | This is the anatomy where you have cola of the plant, you have |
|
|
54:51 | here, the pistol. And if zoom in typically on the flowers or |
|
|
54:58 | the buds on the cos of these , you'll have these trico that are |
|
|
55:03 | protrusions here and they are biochemical factories for producing cannabinoids and producing tur they |
|
|
55:12 | a specialized anatomy and most of the ingredients are gonna be uh located in |
|
|
55:19 | centralized metabolize droplet where you will have lot of cannabinoid synthesis. So, |
|
|
55:27 | enzymes that will synthesize cannabinoids as well urines, can navigate intermediaries and synthesis |
|
|
55:36 | are located in these disc cells below central metabolite droplet. So there's a |
|
|
55:42 | beautiful anatomy. This is a single uh uh trico and they range typically |
|
|
55:49 | I believe 50 to about 150 micrometers size. So you need about four |
|
|
55:56 | to 10 X magnification to see their , to see their structure properly. |
|
|
56:00 | 40 X magnification. And this is cannabinoids are produced. Uh The major |
|
|
56:07 | that are produced by cannabis plan are even T H C CBD or CD |
|
|
56:12 | cannabis plant does not produce T H . It does not produce delta nine |
|
|
56:16 | H C. So it's not it produces T H C A or |
|
|
56:23 | hydro of acid. So if you cannabis plant raw called, you're consuming |
|
|
56:30 | H C A, there was no effect from T H C A. |
|
|
56:35 | the government placed a can on this that produces T H C A doesn't |
|
|
56:39 | able to produce T H C. schedule one, it actually placed a |
|
|
56:44 | plant, a substance that produces nonintoxicating on schedule one, how this DC |
|
|
56:51 | become a neutral form of T H is through the process of heating or |
|
|
56:58 | with T H C A will have coo H group and you basically eliminate |
|
|
57:04 | acid group and turn it into a phenomenon. The plant cannot do that |
|
|
57:11 | . Cannabis plant can burn itself, itself up, put itself through some |
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57:17 | process, through some bath and turn into a T H C. So |
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57:22 | you can see how a lot of the logic behind the loss is driven |
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57:29 | something else than science. It's driven myth, money, special interest. |
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57:40 | unfortunately, that's the situation. I think that these acidic cannabinoids, |
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57:45 | C A CD G A CD G is I used to call it the |
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57:50 | of all cannabinoids, the mother of major cannabinoids, DH C A and |
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57:54 | D A. There's a huge therapeutic to the cytic cannabinoids. And that's |
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58:00 | I wanted to talk to you about . Well, you consume medicine that |
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58:03 | a positive effect means that it calm your seizure inflammation but you are |
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58:09 | Well, yeah, if you consume , you still stop the seizure, |
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58:12 | still high benefit versus harm. And what your doctor decides, benefit versus |
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58:19 | . Now, here these molecules don't the high effect. So you eliminate |
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58:25 | potential, you know, uh associated of a person feeling intoxicated. |
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58:32 | you have the potential of developing pharmaceutical , pharmaceutical anna, but they're not |
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58:38 | stable. You heat the temperature or changes. So the storage to convert |
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58:44 | neutral kommen, they have to come with the different ways of treating these |
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58:48 | cannabinoids versus neutral, can all three them CD G A, DH D |
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58:54 | and CD D A with hero decarboxylate turn into neutral form C H C |
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59:00 | B G C DB. And let's at our C B one receptor. |
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59:04 | if you recall C B one receptors located presynaptic, right? And they |
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59:12 | this, this synoptic, you have P one receptor, an activation of |
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59:18 | B one receptor will typically inhibit calcium . OK. So it blocks calcium |
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59:26 | and it blocks the circular release here the synapse. So, so if |
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59:34 | activate CV one, you control neural . So end of cannabinoids, we |
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59:40 | they were agonous of C B one they activate C B one, they |
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59:45 | G protein cascade and they activate and this case, they shut down the |
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59:50 | of excitatory or inhibitory neurotransmitters, Everybody remembers that from neural transmission |
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59:57 | OK. Good. So T H will act as an uh C |
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60:04 | One result. C B G is antagonist on CV one. So and |
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60:15 | is negative allosteric modulator. So if antagonist inactivates CD one receptor, then |
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60:22 | allosteric modulator dampens CDC D one So what does that mean? |
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60:30 | that means again that we have in plant, the plant itself produces precursors |
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60:37 | as CD G A that can become G that have a completely opposite effect |
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60:42 | delta nine T H C one is agonist that causes a height of |
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60:48 | C B G is an antagonist in moment. So it, it |
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60:54 | it, it doesn't seem right that of them would also, you |
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60:57 | schedule one if one is the bad to see them as potentially almost like |
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61:03 | antidote or something that regulates T H A activity at C B one receptor |
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61:08 | the opposite direction. Physiological direction. general, cannabis has sometimes it's called |
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61:17 | , a plant of 1000 molecules. has at least 500 plus compounds. |
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61:23 | 1520 or so phyto cannabinoids, 120 aromatic molecules that are also produced in |
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61:32 | other molecules such as flavonoids and amino in different parts of the plant. |
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61:38 | now these are the effects that have reported on T H C and CBD |
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61:44 | CD G. So with T H , it causes a high effect. |
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61:48 | also a inflator Nero protective analgesic stimulant, anti anti cancer. Does |
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61:55 | mean we have all of these pharmaceutical that I? No? But if |
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61:59 | look at the Texas uh Department of Safety B P S that controls |
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62:06 | the, the Texas, the, Texas program, you know, |
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62:10 | there's cancer there, there's epilepsy there there's over 100 neurological disorders. There's |
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62:16 | again, there's no pharmaceutical drugs, not a federally accepted system, but |
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62:20 | is a lot of it does that that. Yeah, and because it |
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62:25 | not lethal, that's why the local allowed the people to try it. |
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62:30 | side effects you see can cause anxiety panic attacks and it can be bad |
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62:35 | a lot of people can abuse So those, those people, if |
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62:40 | need to use cannabis for medicinal they may not be able to use |
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62:44 | H C at all. There's too paranoia, too much panic and the |
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62:49 | effects uh increases heart rate. It low rate of the tendencies of one |
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62:56 | 10, 1 in 11. Uh is called cannabis use disorder, but |
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63:01 | they're functional. So people that have use disorder of defendants in cannabis are |
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63:07 | members of society. Um and uh of them run these multibillion dollar companies |
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63:15 | are on stock exchange, all the publicly traded companies, the CEO S |
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63:20 | those companies that have hundreds of employees such. So there is of course |
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63:27 | different dependency when you talk about when you talk about cocaine, when |
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63:31 | talk about alcohol, which one is dangerous just for depends on an |
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63:38 | you know, addiction or dependency and it's there and how and how people |
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63:43 | with it. It's a very complex hyper syndrome. So high concentrations there |
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63:49 | now these concentrate preparations from cannabis and concentrations of T H C can cause |
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63:56 | neis. It's really painful, it's in the stomach, difficult to |
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64:00 | Uh very uh strong coughing bouts and typically in the morning from the users |
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64:08 | consume high levels of T H So it also has side effects on |
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64:13 | . So T H C and the of cannabis can start affecting short term |
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64:17 | , it can start affecting long term . It's also pro psychotic psychotic because |
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64:25 | it's prone panic attack, pro pro psychotic, you know, so |
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64:29 | person has psychosis bipolar depression. This not the phyto cannabinoid that a supervising |
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64:36 | will probably talk to that person We probably talk about CBD which is |
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64:41 | psychotropic. It's psychoactive psycho non psychotropic it's nonintoxicating. What else is |
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64:49 | Almost everything you consume. Caffeine is . Why is it psychoactive? It |
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64:54 | to the dent of receptor and controls release CBD binds to CD receptors, |
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65:02 | in this case, in a different . Glutamate. Ok. Uh It |
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65:06 | counteract negative effects of T H It can be anti psychotic, not |
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65:10 | protective that all of these positive effects reported from CBD. And I don't |
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65:16 | you to know all of these. just want you to know that there's |
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65:19 | effects and there's also negative effects. mild side effects of the CBD. |
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65:24 | doses of CBD can cause fatigue, and indigestion. But in clinical trials |
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65:29 | in the studies of CBD as pharmaceutical , there's very low rate of withdrawal |
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65:35 | patients from those trials, meaning that , it's not bothering that many people |
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65:39 | it doesn't have that many side effects B G. That's where we don't |
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65:44 | a lot except we know that it CD, one antagonist, partial agonist |
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65:49 | CD two, a lot of these . In fact, CBD also will |
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65:56 | with serotonin. CBD is an agonous serotonin receptor. CV G is an |
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66:03 | and it will interact with other So we don't know much about CV |
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66:07 | which is really the core molecule of cannabis plant. But there are anecdotal |
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66:12 | of uh positive effects of anxiety, and opposing negative effects of T H |
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66:20 | because CV G is an antagonist of B one receptor and T H C |
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66:23 | an agonist of CD one receptor. now you see how this picture is |
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66:29 | complicated with just three major cannabinoids, of these effects and all of these |
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66:35 | conditions that helps and only two drugs that are available for two conditions through |
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66:41 | pharmaceutical prescriptions. Just a reminder we're here in this country, we still |
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66:49 | just this available 10% CD D plan synthetic T H C tablets. If |
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66:57 | want to tell you sea ball or the disk or anywhere, that's, |
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67:01 | maybe um given certain conditions, you get a subscription to it. Uh |
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67:08 | know, this is now a report 2017. Actually, it's a report |
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67:16 | the National Academy of Sciences, Engineering Medicine. We got together the smartest |
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67:23 | , engineers and doctors, together over of them. And they said, |
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67:27 | can you tell us if this cannabis any positive therapeutic effect that this is |
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67:33 | BS? So all of these smart went and searched literature, all the |
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67:39 | , all the resources they had, came up with this report in |
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67:44 | which is now dated 60 years ago . But that report said that this |
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67:48 | of substantial evidence that cannabis or cannabinoids effective with the treatment of chronic pain |
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67:54 | adults antis and the treatment of chemotherapy nausea and vomiting cannabis or can when |
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68:04 | say cannabis, they mean the plant improving patient reported multiple sclerosis specific in |
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68:13 | of oral phenomenons. There's no pharmaceutical for pain for cannabinoids in the United |
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68:24 | . There is only one for spasms pain and multiple sclerosis in UK and |
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68:32 | antia metic anti vomiting, anti chemotherapy, induced nausea and vomiting. |
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68:39 | many people are having chemo, how people having cancer? And there is |
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68:45 | variety of natural phyto Cannavino preparations that pharmaceutical preparations to date. And that's |
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68:53 | this this this pathway is a long . There's moderate evidence on other uh |
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68:59 | such as short term sleep, chronic , uh obstructive sleep apnea, limited |
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69:06 | that are affected for HIV AIDS, syndrome, anxiety symptoms, limited evidence |
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69:13 | this limited evidence of this limited evidence this reducing depressive symptoms. So there's |
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69:18 | lot of evidence, a lot of is limited evidence. Ok. I'm |
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69:22 | end the lecture today here and we'll have to get together on 4 20 |
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69:27 | talking about the rest of the, , medical canna. So I'll see |
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69:32 | on Thursday. |
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