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00:00 So the reason why I want to you about the maps I want to

00:07 bending your minds and challenging yourself from you understand the brain. Because the

00:14 belongs to you to your brains and there are many different pathways that one

00:24 take in life. Thio seek The most important pathway that I told

00:32 about is the passion is what you passionate about. And then you can

00:40 about How do I get there is M D that I need to get

00:46 . Can I get there with What is the ultimate goal?

00:52 What? What is really the ultimate that you seek in your career?

00:56 it a degree that you're seeking my ? Is it money that you see

01:00 a discovery and you don't care? just want to study flies and how

01:05 reproduce. And what is it? is driving you? This is the

01:11 important thing in choosing your career and how you apply things. Also,

01:15 forget the road is wind e. we talked about Roderick MacKinnon and Potassium

01:22 MD, who decided to study potassium structure and function of potassium channels using

01:29 toxins so many different ways you can there. One of the most

01:35 um, scientists Neurologist for me is la Rionda Ramachandran. And we're now

01:44 to watch a 23 minute long a Ted video on three conditions that

01:51 describes if he engages his scientific and mind. If he engages all,

02:00 has abilities in understanding these conditions, the solutions and sometimes finding solutions that

02:07 very simple and sometimes low cost Three conditions. That will be a

02:15 on examine each one of these three . So without further ado, there's

02:22 brilliant at talk, and I will the link on blackboard. Brilliant Ted

02:32 . Bye, Rama Chandra. Um , um, Chris pointed out I

02:44 the human brain functions and structure of human brain, and I just want

02:48 to think for a minute about what entails. Here is this mass of

02:53 £3 mass of jelly you can hold the palm of your hand and it

02:58 contemplate the vastness of interstellar space. can contemplate the meaning of infinity,

03:05 it can contemplate itself contemplating on the of infinity. And there's this peculiar

03:11 quality that we call self awareness, I think is the holy Grail of

03:16 , of Neurology. And hopefully, we'll understand how that happens.

03:22 so how do you study this mysterious ? I mean, you have 100

03:27 nerve cells, little wisps of protoplasm with each other, and from this

03:32 emerges the whole spectrum of abilities that call human nature and human consciousness.

03:38 does this happen? Well, there many ways of approaching the functions of

03:41 human brain. One approach, the we use mainly, is to look

03:45 patients who have sustained damage to a region of the brain. There's been

03:50 genetic change in a small region of brain. What then happens is not

03:54 across the board reduction in all your capacity to sort of blunting of your

03:59 ability. What you get is a selective loss of one function, with

04:03 functions being preserved intact, and this you some confidence in asserting that that

04:08 of the brain is somehow involved in that function. So you, in

04:12 map, function onto structure and then out what the circuitry is doing to

04:17 that particular function. So that's what trying to do. So let me

04:22 you a few striking examples of If I give you three examples six

04:26 each. During this talk, the example is an extraordinary syndrome called Cop

04:31 syndrome. If you look at the light them, that's the temporal

04:36 Frontal lobes, parietal lobes. the lobes that constitute the brain.

04:47 if you look tucked away inside the surface of the temporal lobes you can't

04:51 . That is a little structure called form gyros that's been called the face

04:57 in the brain, because when it's , you can no longer recognize people's

05:01 . You can still recognize them from voice, said. Oh yeah,

05:04 Joe, but you can't look at face and know who it is.

05:08 can't even recognize yourself in the I mean, you know it

05:11 It's you because when you wink, may winks and you know it's a

05:14 , but you don't really recognize yourself as yourself. Okay, now that

05:20 is well known as caused by damage the physical embarrassed, but There's another

05:23 syndrome so rare, in fact, very few physicians have heard about

05:27 not even neurologists. This is called Cop craft Delusion, and that is

05:32 patient who's otherwise completely normal. Had head injury, comes out of

05:37 otherwise completely normal. He looks at mother and says, This looks exactly

05:42 my mother, this woman. But an impostor. She's some other woman

05:46 to be my mother. Now, does this happen? Why would somebody

05:49 this person is perfectly lucid and intelligent all other respects? But when he

05:53 his mother, his delusion kicks says not mother. Now the most

05:57 interpretation of this, which you find older psychiatry textbooks, is a Freudian

06:03 , and that is that. This and same argument applies to women,

06:06 the way. But I'll just talk guys when you're a little baby in

06:10 young baby. You had a strong attraction to your mother. This is

06:14 so called Oedipus complex of Freud. not saying I believe this, but

06:17 is the starting standard Freudian view, then as you grow up, the

06:22 develops and inhibits these latent sexual urges your mother. Thank God. Otherwise

06:28 all be sexually aroused when you saw mother. And then what happens is

06:33 a blow to your head damaging the , allowing these latent sexual urges to

06:39 flaming to the surface and suddenly and , you find yourself being sexually aroused

06:44 your mother, he said. My , this is my mom. How

06:46 I'm being sexually turned on? She's other woman. She's an impostor,

06:50 only interpretation that makes sense to your brain. This never made much sense

06:56 me. This argument. It's very , as all Freudian arguments are,

07:03 make money sense. Much sense because have seen the same delusion. A

07:07 having the same delusion about his pet . He'll say, Doctor, this

07:13 not fi fi. It looks exactly 50 but it's some other dog right

07:18 . You try using the Freudian explanation you have. You have to start

07:22 about the latent beast reality in all or some such thing, which is

07:26 absurd. Of course. Now what's going on? So to explain this

07:31 disorder, we look at the structure functions off the normal visual pathways in

07:35 brain. Normally, visual signals come into the eyeballs. Go to the

07:39 areas in the brain. There in fact, 30 areas in the

07:42 of your brain, concerned with just . And after processing all that,

07:45 message goes to a small structure called form gyros, where you perceive

07:52 There are neurons there that are sensitive faces. You can call it the

07:55 area of the brain, right? talked about that earlier. Now,

07:59 that area's damaged, you lose the to see faces, right. But

08:03 that area, the message cascade into structure called the amygdala. In the

08:08 system, the emotional core of the and that structure, called the

08:12 gauges the emotional significance of what you're at. Is it prey? Is

08:16 predator? Is it mate, or there something absolutely trivial, like a

08:20 of lint or a piece of Or are I don't want to point

08:24 that, but or a shoe or like that, OK, which you

08:27 completely ignore. So if the amygdala excited and this is something important,

08:32 messages then cascade into the autonomic nervous . Your heart starts beating faster.

08:36 start sweating to dissipate the heat that gonna create from exerting muscular exertion.

08:43 that's fortunate because you can put two on your palm and measure the change

08:47 skin resistance produced by sweating So I determine when you're looking at something,

08:51 you're excited or whether you're aroused or . Okay, and I'll get to

08:55 in a minute. So my idea , when this chap looks at an

09:01 when he looks at his, any for that matter, it goes to

09:04 visual areas. Andi, however, it's processed in the physic form

09:08 and you recognize it as a pea or a table or your mother,

09:13 that matter. OK, and then message cascades into the amygdala and then

09:17 down the autonomic nervous system. But in this chap, that wire that

09:22 from the amygdala to the limbic the emotional core of the brain is

09:26 by the accident. So because the of farmers intact, the chap can

09:30 recognize his mother and says hope, , this looks like my mother.

09:34 because the wire is cut to the centers is. But how come it

09:38 my mother? I don't experience a or terror as the case may be

09:45 , and therefore, he says, do I account for this inexplicable lack

09:49 emotions? This can't be my It's some strange woman pretending to

09:53 My mother, How do you test ? Well, what do you do

09:56 you take any one of you here put you in front of,

09:58 screen and measure your galvanic skin response show pictures on the screen? I

10:03 measure how you sweat when you see object like a table or an

10:07 Of course, you don't sweat. I show you a picture of a

10:10 or a tiger or a pinup, start sweating, right? And believe

10:14 or not, if I show you picture of your mother, I'm talking

10:17 normal people. You start sweating. don't even have to be Jewish.

10:23 , Now what happens? What happens you show this patient? You take

10:28 patient and show him pictures on the measure his galvanic skin response tables and

10:34 and lint. Nothing happens, as normal people, but when you show

10:38 a picture of his mother. The skin response is flat. There's no

10:43 reaction to his mother because that wire from the visual areas to the emotional

10:48 is cut. So his vision is because the visual areas are normal.

10:52 emotions are normal. He'll laugh. cry so on and so forth.

10:55 the wire from vision to emotions is , and therefore he has this delusion

10:59 his mother is an impostor. It's lovely example of what sort of thing

11:03 do. Take a bizarre, seemingly Europe psychiatrist syndrome and say that the

11:09 Freudian view is wrong, that in , you can come up with a

11:13 explanation in terms of the no neuro of the brain. By the

11:16 this patient then goes on mother phones an adjacent room, phones them and

11:22 picks up the phone, he while Mom, how are you?

11:25 are you? There's no delusion through phone. Then she approaches him.

11:30 an hour, he says, Who you? You look just like my

11:32 , Okay? The reason is there's separate pathway going from the hearing centers

11:36 the brain to the emotional centers, that's not being cut by the

11:41 So this explains why with a he recognizes his mother no problem.

11:45 he sees it in person. He It's a deal, he says.

11:48 an impostor. OK, how is this complex circuitry set up in the

11:53 ? Is it nature genes, or it nurture? And we approach this

11:57 by considering another curious syndrome called phantom . And you all know what a

12:02 limb bez button arm is amputated or leg is amputated for gangrene or you

12:07 it in war, for example, the Iraq war, it's now a

12:10 problem. You continue to vividly feel presence of that missing arm, and

12:15 called a phantom arm or a phantom . In fact, you can get

12:18 phantom with almost any part of the , believe it or not, even

12:21 internal viscera, I've had patients with uterus removed hysterectomy who have a phantom

12:29 , including phantom menstrual cramps at the time of the month. And in

12:35 , one student asked me the other , Do they get Phantom PMS?

12:38 huh. A subject ripe for scientific , but we haven't pursued that.

12:44 , now the next question is, can you learn about phantom limbs by

12:48 experiments? One of the things we was about half the patients with phantom

12:52 claim that they can move the It'll pat his brother on the

12:56 It'll answer the phone. When it , it'll wave goodbye. These are

12:59 compelling, vivid sensations, patients not . He knows that the arm is

13:03 there, but nevertheless, it's a sensory experience for the patient.

13:08 however, about half the patients, doesn't happen. The phantom limb,

13:13 say the doctor. The phantom limb paralyzed. It's fixed in a clenched

13:17 is excruciatingly painful. If only I move it. Maybe the pain will

13:21 relieved. Now, why would a limb be paralyzed? It sounds like

13:25 oxymoron. When we looked at the sheets, what we found Waas thes

13:30 with the paralyzed phantom limbs. The arm was paralyzed because of the peripheral

13:35 injury. The actual nerve supplying the was severed was cut by,

13:40 a motorcycle accident, so the patient an actual arm, which is painful

13:44 a sling for a few months or year, and then, in a

13:48 attempt to get rid of the pain the arm, the surgeon amputated the

13:52 . And then you get a phantom with the same pains, right?

13:57 this is a serious clinical problem. become depressed. Some of them are

14:01 to suicide. Okay, so how you treat this syndrome now? Why

14:06 you get a paralyzed phantom limb? I looked at the case sheet.

14:08 found that they had an actual The nerves supplying the arm had been

14:14 and the actual arm had been paralyzed lying in a sling for several months

14:19 the amputation. And this pain then carried over into the phantom itself.

14:27 does this happen? When the arm intact but paralyzed, the brain sends

14:31 to the arm, the front of brain saying move ! But it's getting

14:34 feedback, saying No move, no , no move, no. And

14:40 gets wired into the circuitry of the and we call this learned paralysis.

14:46 , the brain learns because of this in associative link that the comeere command

14:52 move the arm creates a sensation of paralyzed arm. And then when you

14:56 the arm, this learned paralysis carries into the into your body. Image

15:02 into your phantom. Okay, how do you help these patients?

15:06 do you unlearn the learned paralysis so can relieve him of this excruciating clenching

15:12 off the phantom arm? Well, said, what if you now send

15:17 command to the Phantom, but give visual feedback that is obeying his

15:22 Right. Maybe you can relieve the pain. The Phantom clan. How

15:26 you do that? Well, virtual , but that cost millions of

15:29 So I hit on a way of this for $3. But don't tell

15:33 funding agencies. Okay? What you , you create what I call a

15:39 box. You have a cardboard box a mirror in the middle, and

15:42 you put the Phantom. So my patient data came in. He had

15:46 arm amputated 10 years ago. He a brachial avulsion, so the nerves

15:50 cut. The arm was paralyzed, in a sling for the year.

15:54 then the arm was amputated. He a phantom arm, excruciatingly painful,

15:57 he couldn't move. It was a phantom long. So you came there

16:01 I gave him a mirror like that a box. Okay, what I

16:04 a mirror box right on the patient his phantom left arm, which is

16:10 and in spasm on the left side the mirror and the normal hand on

16:13 right side of the mirror and makes same posture, the clenched posture and

16:18 inside the mirror. And what does experience? He looks at the phantom

16:23 resurrected because he's looking at the reflection the normal arm in the mirror,

16:28 it looks like this phantom has been . Now, I said, Now

16:32 , wiggle your phantom. You're really or move your real fingers while looking

16:36 the mirror is going to get the impression that the phantom is moving

16:40 That's obvious, but the astonishing thing the patient then says, Oh my

16:44 , my phantom is moving again. the pain, the clenching phantom is

16:48 . I remember my first patient, came in. My first patient came

16:57 and he looked in the mirror and said, Look at your reflection of

17:01 Phantom he's and he started giggling because can see my Phantom. But he's

17:04 stupid. He knows it's not really knows it's a mirror reflection, but

17:07 a vivid sensory experience now. I Move your normal hand and phantom He

17:12 . All I can't move my You know that it's painful. I

17:15 , Move your normal hand He Oh my God, my phantom is

17:18 again. I don't believe this on pain is being relieved, OK?

17:22 then I said, Close your eyes close his eyes and move your normal

17:25 . Oh, nothing. It's clenched . OK, open your eyes.

17:29 my God ! Oh my God, moving again. He's like a kid

17:31 a candy store. So I OK, this proves my theory about

17:36 paralysis and the critical role of visual . But I'm not going to get

17:40 Nobel Prize for getting somebody to move phantom limb. Completely useless ability,

17:47 you think about it. But But I started realizing maybe other kinds of

17:53 that you see in in neurology like focal dystonia. There may be a

17:58 component to this which you can overcome the simple device of using a

18:03 So I said, Look, Well, first of all, the

18:05 can't just go around carrying a mirror alleviate his pain. I said,

18:08 , Derek, take it home and with it for a week or

18:12 Maybe after repeated practice, you can with the mirror, unlearn the paralysis

18:16 start moving your paralyzed arm and then yourself of pain. So he

18:21 Okay and you took it home. said, Look, it's after all

18:23 . Take it home. So you it home and after two weeks he

18:26 me and he said, Talk to not gonna believe this. I said

18:30 . He said, It's gone. said, What's gone? I thought

18:32 the mirror box was gone. He , No, no, no.

18:36 know this phantom I've had for the 10 years, it's disappeared and I

18:41 I got worried. I said, God, I mean, I've changed

18:44 guy's body image. What about human , ethics and all of that?

18:47 I said, Derek, does this you? He said, No.

18:50 three days I've not had a phantom and therefore no phantom elbow pain.

18:55 clenching, no phantom forearm pain. those pains have gone away, But

18:59 problem is I still have my phantom dangling from the shoulder and your box

19:04 reach. So can you change the and put it on my forehead so

19:09 can, you know, do this eliminate my phantom fingers? I he

19:13 it was some kind of magician. this happen? Is because the brain

19:16 faced with tremendous sensory conflict. It's messages from vision saying the Phantom is

19:21 . On the other hand, there's appropriate reception muscle signals saying that there

19:25 no arm right and your motor command there is an arm. And because

19:30 this conflict, the brain says, hell with it. There is no

19:33 . There is no arm right. goes into a sort of denial.

19:35 gates the signals when the arm The bonus is the pain disappears because

19:41 can't have disembodied pain floating out there space. So that's the bonus.

19:46 . This technique has been tried on of patients by other groups in

19:49 so it may prove to be valuable a treatment for Phantom pain. And

19:53 people have tried it for stroke Stroke, you normally think, offers

19:58 to the fibers. Nothing you can about it. But it turns out

20:02 component of stroke paralysis has also learned , and maybe that component can be

20:08 using mirrors. This has also gone clinical trials, helping lots and lots

20:12 patients. OK, let me switch now to the third part of my

20:22 , which is about another curious phenomenon synesthesia. This discovered by Francis Galton

20:28 the 19th century. He was a of Charles Darwin. He pointed out

20:32 certain people in the population what otherwise normal had the following peculiarity. Every

20:38 they see a number, it's Five is blue. Seven is

20:43 Eight is chartreuse. Nine. Is OK, Bear in mind, these

20:47 are completely normal in other respects. , or C sharp. Sometimes tones

20:52 color. C sharp is blue. sharp is green. Uh, another

20:56 might be yellow, right? Why this happen? It's called synesthesia.

21:01 called it synesthesia. Mingling of the , You in us all the senses

21:05 distinct. These people muddle of their . Why does this happen? Another

21:09 aspects of this problem a very intriguing runs in families. So Dalton

21:14 this is a hereditary basis, a basis. Secondly, synesthesia is

21:18 and this is what gets me My point about the main theme of

21:22 election is about creativity. Synesthesia is times more common among artists,

21:27 novelists and other creative people than in general population. Why would that

21:31 I'm going to answer. That question never been answered before. Okay,

21:36 is synesthesia? What causes it will their many theories. One theory is

21:39 just crazy. Now. That's not a scientific theory, so you can

21:43 about it. Okay, Another theory they are acid junkies and potheads,

21:47 ? There may be some truth to because it's much more common here in

21:50 Bay Area than in San Diego. , now, the third theory is

21:56 well, let's ask ourselves what's really on in synesthesia? Alright, so

22:01 the color area and the number area next to each other in the brain

22:05 the future form gyros. So we there's some accidental cross wiring between color

22:10 numbers in the brain. So every you see a number, you see

22:13 corresponding color, and that's why you synesthesia. Now, remember, Why

22:18 this happen? Why would they be wired in some people? Remember,

22:21 said, it runs in families. gives you the clue. And that

22:25 , there is an abnormal gene. in the gene that causes this abnormal

22:29 wiring in all of us, it out we're born with everything wired to

22:34 else. So every brain region is to every other region, and these

22:38 trimmed down to create the characteristic modular of the adult brain so that there's

22:44 gene causing this trimming. And if gene mutates, then you get deficient

22:49 between adjacent brain areas. And if between number and color, you get

22:53 color. Synesthesia has been toned in . You get tone color synesthesia.

22:56 far, so good. Now what this gene is expressed everywhere in the

23:00 , so everything is cross connected? , think about what artists, novelists

23:06 poets have in common. The ability engage in metaphorical thinking. Linking seemingly

23:12 ideas such as it is the East Juliet is the sun. But you

23:16 say Juliet is the sun. Does mean she's a glowing ball of

23:20 I mean, schizophrenics do that, it's a different story, right?

23:23 people say she's warm like the She's radiant, like the sun she's

23:27 , like the sun instantly form the . If you assume that this greater

23:32 wiring and concepts are also in different of the brain, then it's going

23:36 create a greater propensity towards metaphorical thinking creativity in people with synesthesia. And

23:44 the eight times more common incidents off among poets, artists and novelists.

23:48 , it's a very fraternal, logical of synesthesia. The last demonstration cannot

23:52 one minute. Okay, you are sinners, steets, but you're in

24:00 about it. Here's what I call alphabet, just like your alphabet.

24:04 is a B S B, C C. Different shapes for different

24:09 Right here. You've got Martian One of them is Kiki. One

24:13 them is Buba. Which one is ? And which one is? But

24:16 many of you think that's Kiki? that's Buba. Raise your hands.

24:19 , it's one or two mutants. many of you think that's Buba?

24:22 Kiki. Raise your hands. 99% you. Now you. None of

24:26 is a Martian. How did you that? It's because you're all doing

24:30 Model Sinise. Thet IQ abstraction. ? You're saying that that sharp inflection

24:36 in your auditory cortex, the hair being excited key mimics the visual

24:43 sudden inflection of the jagged shape. this is very important because what it's

24:47 you is your brain is engaging in primitive just it looks like a silly

24:52 . But these photons in your eye doing this shape and hair cells in

24:57 year. Exciting the auditory pattern, the brain is ableto extract the common

25:03 . It's a primitive form of and we now know this happens in

25:08 refusal form gyrus of the brain. when that's damaged, these people lose

25:13 ability to engage in Buba Kiki. they also lose the ability to engage

25:17 metaphor. If you ask this guy all that glitters is not gold,

25:21 does that mean? The patient Well, if it's metallic and shiny

25:25 mean it's gold, you have to its specific gravity Okay, so they

25:29 miss the metaphorical meaning. So this is about eight times the size in

25:34 , especially in humans, as in primates. Something very interesting is going

25:38 here in the angular gyrus because it's crossroads between hearing vision and touch,

25:45 in humans. And something very interesting going on. I think it's a

25:48 off many uniquely human abilities like metaphor and creativity. All of these

25:54 that philosophers have been studying for We scientists can begin to explore by

25:59 brain imaging and by studying patients and the right questions. Thank you.

26:04 about that e,

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