| 00:00 | Let's see what happens. But in case, so that's, you |
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| 00:04 | like there's also these things fillers, fillers will actually fill the space, |
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| 00:08 | know, with whatever they're injecting in cosmetics party. But Botox will prevent |
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| 00:15 | release off Siddle, Kolding and basically activation. The other reason is, |
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| 00:24 | , you can actually now have an approved Botox injections. Thio treat |
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| 00:33 | Eso that's that's That's quite interesting, . So it's too partisan cosmetics party |
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| 00:38 | make yourself look beautiful. Wrinkle at least temporarily on the second |
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| 00:46 | is alleviating neurological condition by by preventing neurotransmitter release and interfering with the migraine |
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| 00:57 | . There's other, um, toxins and other chemicals that also interact with |
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| 01:06 | silk cooling system. Here, black spiders that are pictured black widow spiders |
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| 01:18 | venom that is extremely powerful, and also interferes with acetylcholine. Release eso |
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| 01:30 | again. Things in nature, about believe about 2000 people every year |
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| 01:37 | bid by black widow spiders and but it can be deadly. |
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| 01:44 | Taiwanese Cabra. We'll have Alfa Bunger , which will affect mawr of the |
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| 01:51 | Athletic. That's a towel cobian receptor . So most of the things that |
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| 01:56 | talking here. A pre synaptic black widows and Bangalore toxin is now |
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| 02:02 | to affect Boston Optic, which we're to talk about the receptors. And |
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| 02:07 | we have a lot of bad things are synthesized by humans too, not |
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| 02:16 | by nature and microbes and nature, by humans. And those air organophosphates |
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| 02:26 | , organa fost fades are nerve. is they are so hman Sorry in |
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| 02:38 | other nerve gas is, uh and are Actually, it's a towel called |
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| 02:48 | race inhibitors. And so let zlook Let's look at this diagram now I |
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| 02:57 | forward on purpose. Let's drill this our seal Colleen system. We're going |
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| 03:05 | study the synthesis and breakdown. Acetyl . It is becoming one when Colleen |
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| 03:13 | the cyclical coleene come together and Okay, so this is a synthesizing |
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| 03:21 | is chat, which is Kaleena Siegel , making a civil Colin molecule that |
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| 03:27 | civil Colin molecule gets loaded up into vesicles. That's a steal coding molecule |
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| 03:34 | released into the synaptic cleft. There two types of acetylcholine receptors. |
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| 03:42 | optically big bang, bang bang Last lectures Question. How come a |
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| 03:50 | Colin slows down the heart trade, speeds up the skeletal muscle contraction. |
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| 03:58 | newer muscular junction, We said there only one type of receptor nicotine IQ |
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| 04:03 | receptor that causes muscle contraction. There's type of acetylcholine receptor must Quranic CEO |
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| 04:12 | Receptor, and we'll understand more about . We'll talk more about it, |
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| 04:16 | don't worry about it. But most receptor, which is causing the opposite |
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| 04:21 | it depends on the receptor depends what expressed by these organs. When Macedo |
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| 04:27 | gets released in the CNS synapses, binds to both of these receptors, |
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| 04:34 | nicotine IQ and muscular nick receptors. neurons binds to these receptors, but |
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| 04:41 | doesn't stay in the synaptic class for very long time, and it gets |
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| 04:46 | down by a C H e. a little Colin s. Therese takes |
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| 04:52 | single Colin and breaks it down into acid on polling. So a serial |
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| 04:59 | Nestor race we'll break it down into in a city. Kassid. There |
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| 05:05 | be a cooling transporter in the pre membrane that will transport calling back |
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| 05:13 | will command and synthesize acetylcholine again from . Acetyl coa, a and reload |
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| 05:21 | with the Seattle Colleen molecules again. , so these vesicles are now ready |
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| 05:27 | fuse. Release the civil code and nicotine nick and muscular neck. Nicotine |
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| 05:32 | is a channel receptor and muscular neck you will learn is a G protein |
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| 05:38 | receptor. So this still coleene esta . This is still Colin esta rates |
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| 05:46 | what breaks down acetylcholine and in We have that medications for Alzheimer's |
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| 05:53 | a lot of medications for Alzheimer's and you will see even commercials on |
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| 06:01 | on since. See I am if taking See I am or this is |
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| 06:06 | CME. If you're taking CMU, thio watch for the contrary, to |
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| 06:11 | into indications or reactions with this. ? Because we already discussed last |
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| 06:18 | That and Alzheimer's disease. A single neural transmission on Colin Ergic circuits are |
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| 06:27 | seriously, an impact that some of earliest nerve is ne neuronal synaptic transmission |
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| 06:36 | on the brain. So what? type and most of the medications for |
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| 06:43 | that fall under this type do is inhibit us still called anesta rates by |
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| 06:50 | acetyl colonist a raise, they are the levels they're raising the availability of |
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| 06:59 | Cecile Colin. It's referred to us availability. How available is the |
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| 07:04 | Locally in the presence of Macedo Colonist , it's not very available, gets |
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| 07:10 | down. But if you block a cull anesta rates. You increase the |
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| 07:17 | . You increase the concentration of the Colleen in these sinner absence. Then |
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| 07:24 | pretty awesome. But it's pretty And most of the multi billion dollar |
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| 07:31 | driving Alzheimer's medication can only slow down progression of the disease. Because think |
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| 07:39 | it. If you're not synthesizing a Colin, blocking the degradation of the |
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| 07:46 | colon is not gonna increase the synthesis Macedo Colin. So we could |
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| 07:52 | Then people are neuro pharmacologists getting into to synthesize how Thio make these a |
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| 07:58 | Colin neurotransmitters the pre synaptic cells active and viable with the Seattle Khalid |
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| 08:06 | this precursor molecules or something else. medications for Alzheimer's are a civilian calling |
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| 08:16 | race inhibitors. They inhibit the hands that breaks down the civil calling, |
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| 08:23 | make sure, as I said, be adding information on different neurological |
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| 08:29 | This goes on the Alzheimer's disease, this also goes under the synthesis, |
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| 08:37 | , degradation a seal calling breakdown. , call me. And so I'd |
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| 08:44 | to discuss this in the light. last topic here of Organophosphates Organa. |
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| 08:53 | states and nerve gasses are a C E s, which are as the |
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| 09:02 | Colin Astor raise inhibitors. And so gas is, you can still say |
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| 09:13 | extremely relevant. There are some countries are stockpiling nerve gas is for the |
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| 09:23 | . You can see that Russians air poisoning their opposition leaders and Ukrainian and |
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| 09:34 | spies. Uh, that go on , the side poisoning them with with |
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| 09:41 | substances. So the latest one was leader to put in the gut poisoned |
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| 09:46 | these nerve gasses. Germans are studying . They dragged him out of the |
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| 09:51 | . So German snow, the specifications these chemicals? Exactly. We can |
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| 09:56 | down what lives that were made in Russia. Uh, it hasn't been |
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| 10:02 | on populations. It has. It's . It has been used in warfare |
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| 10:09 | towns that has been used in terrorist . Uh, Tokyo Metro attack in |
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| 10:14 | early nineties was nerve gas is on in Iraq. About five years |
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| 10:22 | I had an honor off having a special service, uh, special |
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| 10:31 | , students in my class who was in in in Fallujah and describe to |
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| 10:39 | he was he was a medic. described to me a situation because once |
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| 10:45 | get exposed to the organophosphates thio, you have construction of your pupils and |
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| 10:51 | have difficulty of breathing. But then can die within a couple of |
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| 10:57 | And so most of the military and of the medics, they haven't |
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| 11:04 | which is essentially, uh, The availability is an antidote that they |
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| 11:11 | quickly inject to save in case of nerve gas explosion. So, of |
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| 11:17 | , in the warfare, when everybody equipped this the course could be |
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| 11:21 | But essentially, what happens if it's much? It's until Cole name. |
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| 11:28 | your muscle goes into this very intense , and it goes into what we |
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| 11:34 | a tetanus and the shock where the remains deep, polarized and contracted and |
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| 11:39 | relax anymore. And for anything for or contraction, you have to |
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| 11:46 | Relax, contract. Relax, because you hold anything contracted, you will |
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| 11:51 | that your skeletal muscles get very, tired. And what happens with the |
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| 11:56 | that surround your breathing systems is that can eventually shut down your breathing |
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| 12:02 | within a few minutes of time or , um, so we'll come back |
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| 12:08 | review some of this material on the . And again, we'll review the |
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| 12:12 | coleene system, signaling. I'm going see what's happening in the charts, |
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| 12:22 | I cannot open it for some Uh, let me come out of |
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| 5999:59 | |
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